Purpose: To compare the clinical outcomes of intracorneal ring segment (ICRS) implantation in eyes with advanced vs. mild/moderate keratoconus (KCN).
Methods: A retrospective analysis of 141 eyes of 111 patients with KCN who underwent ICRS implantation. Preoperative maximum keratometry (Kmax) was <57 diopters (D) in 70 eyes and >57 D in 71 eyes. Postoperatively, corrected distance visual acuity (CDVA), Kmax, and intraoperative and postoperative complications were assessed at 1 day, 1 month, and 1 year.
Results: Corneas with a preoperative Kmax >57 D experienced greater reduction in axial curvature after ICRS implantation than corneas with a preoperative Kmax <57 D (7.0 D vs. 5.5 D, =0.005) and gained more Snellen lines of CDVA (3 vs. 1, <0.001) by 1 year postoperatively. The incidences of the most prevalent complications (explantation, extrusion, and infectious keratitis) did not differ significantly between the two groups (p=0.29, p=0.99, p=0.98).
Conclusions: The visual and topographic effects of ICRS implantation are greater in eyes with more advanced KCN, with no increase in the incidence of the most common complications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1177/11206721231155213 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Clinical outcomes of two symmetrical Kera-rings implanted in grade three keratoconus: a retrospective nonrandomized study.
BMC Ophthalmol
December 2024
Ophthalmology Department, Faculty of Medicine, Sohag University, Almohafza St. Mailbox: 82511, Sohag, 82511, Egypt.
Purpose: To evaluate the clinical outcomes of implanting two symmetrical Kerarings via a femtosecond laser in grade three keratoconus.
Patients And Methods: This was a retrospective nonrandomized controlled clinical study. The study included one eye from each of twenty-three patients, all with Grade 3 keratoconus as classified by the Amsler-Krumeich classification.
Femtosecond Laser- Assisted Customized CAIRS In Keratoconus Patients After ICRS Explantation: A Prospective Case Series: Customized CAIRS in post ICRS extrusion keratoconus patients.
J Cataract Refract Surg
December 2024
Department of Ophthalmology, Sorocaba Eye Hospital, Sorocaba Eye Bank, Sorocaba, São Paulo, Brazil.
Purpose: To investigate the effectiveness and safety of customized femtosecond laser-assisted corneal allogenic intrastromal ring segments (CAIRS) implantation in keratoconus patients with a history of intrastromal corneal ring segment (ICRS) explantation.
Setting: Sorocaba Eye Hospital (Hospital Oftalmológico de Sorocaba - HOS), Sorocaba, Brazil.
Design: Prospective case series.
Evaluation of design parameters on the outcome of intrastromal ring surgery using biomechanical simulations.
PLoS One
December 2024
ARTORG Center for Biomedical Engineering Research, University of Bern, Bern, Switzerland.
Background: The cornea plays a role in the refractive power of the eye, and when its natural curvature and thickness are compromised by diseases such as keratoconus or high myopia, this results in loss of visual acuity. Intracorneal rings (ICRs) were developed as a treatment option to restore the natural corneal curvature by implanting rings into tunnels cut within the corneal stroma. However, selecting and placing the appropriate ring can be difficult, and predicting refractive outcomes is challenging.
View Article and Find Full Text PDFArticular cartilage regeneration with a microgel as a support biomaterial. A rabbit knee model.
Biomater Adv
March 2025
Center for Biomaterials and Tissue Engineering (CBIT), Universitat Politècnica de València, Valencia, Spain; CIBER de Bioinginiería, Biomateriales y Nanomedicina, Instituto de Salud Carlos III, Spain.
Articular cartilage has limited regenerative capacity, so focal lesions generate mechanical stress in the joint that induces an aggravation of the damage, which ultimately leads to osteoarthritis. We recently suggested the use of microgels at the site of the cartilage defect, as a support material, to generate a biomechanical environment where pluripotent cells differentiate towards the hyaline cartilage phenotype. Here we propose a chondral regeneration strategy based on subchondral bone injury, and filling the defect site with an agglomerate of two types of microspheres, some rigid made of a biodegradable polyester (40 μm mean diameter), and others with a gel consistency made of platelet-rich plasma obtained from circulating blood (70-110 μm diameter).
View Article and Find Full Text PDFBiphasic cartilage repair implant versus microfracture in the treatment of focal chondral and osteochondral lesions of the knee: a prospective, multi-center, randomized clinical trial.
J Orthop Traumatol
November 2024
Department of Orthopaedic Surgery, National Taiwan University Hospital, 7 Chungsan South Road, Taipei City, 10002, Taiwan.
Background: Autologous minced cartilage is a method for cartilage defect repair, and our study focuses on a newly developed biphasic cylindrical osteochondral construct designed for use in human knees. We aimed to compare its clinical effectiveness and safety with microfracture, the commonly utilized reparative treatment for knee chondral or osteochondral defects.
Materials And Methods: Conducted as a prospective multicenter, randomized controlled, non-inferiority trial across nine hospitals, the study involved 92 patients with International Cartilage Repair Society (ICRS) grade 3 to 4 chondral or osteochondral lesions on femoral condyles.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!