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The perils of open landfill: a study on environmental risk assessment in Dharamshala, Himachal Pradesh, India.
Environ Monit Assess
January 2025
Department of Environmental Sciences, Central University of Himachal Pradesh, Dharamshala, Kangra, Himachal Pradesh, India.
Improper and unscientific management of municipal solid waste (MSW) landfill sites has increasingly become a pressing environmental issue especially in the mountainous regions worldwide. In view of this, an attempt was made to assess the detrimental effects of MSW landfill on the natural water sources at Dharamshala, Himachal Pradesh. Further, the suitability of potential landfill site and dispersion of pollutant air masses were stipulated using Arc GIS and HYSPLIT model.
View Article and Find Full Text PDFNatural products and long non-coding RNAs in prostate cancer: insights into etiology and treatment resistance.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Biochemistry, Faculty of Pharmacy, Badr University in Cairo (BUC), Badr City, , 11829, Cairo, Egypt.
Globally, the incidence and death rates associated with cancer persist in rising, despite considerable advancements in cancer therapy. Although some malignancies are manageable by a mix of chemotherapy, surgery, radiation, and targeted therapy, most malignant tumors either exhibit poor responsiveness to early identification or endure post-treatment survival. The prognosis for prostate cancer (PCa) is unfavorable since it is a perilous and lethal malignancy.
View Article and Find Full Text PDFThe promises and perils of circulating tumor DNA for monitoring immunotherapy response in non-small cell lung cancer.
Explor Target Antitumor Ther
November 2024
Division of Pulmonary, Critical Care, and Sleep Disorders Medicine, Department of Medicine, University of Louisville School of Medicine, Louisville, KY 40202, USA.
There has been a rapid expansion of immunotherapy options for non-small cell lung cancer (NSCLC) over the past two decades, particularly with the advent of immune checkpoint inhibitors. Despite the emerging role of immunotherapy in adjuvant and neoadjuvant settings though, relatively few patients will respond to immunotherapy which can be problematic due to expense and toxicity; thus, the development of biomarkers capable of predicting immunotherapeutic response is imperative. Due to the promise of a noninvasive, personalized approach capable of providing comprehensive, real-time monitoring of tumor heterogeneity and evolution, there has been wide interest in the concept of using circulating tumor DNA (ctDNA) to predict treatment response.
View Article and Find Full Text PDFThe Promise and Perils of Using Peers and Other Paraprofessionals as Mental Health Service Professionals.
JAMA Psychiatry
January 2025
Division of Services and Intervention Research, National Institute of Mental Health, Bethesda, Maryland.
Promises and perils of using Transformer-based models for SE research.
Neural Netw
December 2024
University of British Columbia, ICICS/CS Building 201-2366 Main Mall, Vancouver, BC, Canada.
Many Transformer-based pre-trained models for code have been developed and applied to code-related tasks. In this paper, we analyze 519 papers published on this topic during 2017-2023, examine the suitability of model architectures for different tasks, summarize their resource consumption, and look at the generalization ability of models on different datasets. We examine three representative pre-trained models for code: CodeBERT, CodeGPT, and CodeT5, and conduct experiments on the four topmost targeted software engineering tasks from the literature: Bug Fixing, Bug Detection, Code Summarization, and Code Search.
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