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lncRNA SNHG4 enhanced gastric cancer progression by modulating miR-409-3p/CREB1 axis.
Oncol Res
December 2024
Department of General Surgery, Affiliated Hospital of Nantong University, Nantong, 226001, China.
Objective: Gastric cancer (GC) is a globally common cancer characterized by high incidence and mortality worldwide. Advances in the molecular understanding of GC provide promising targets for GC diagnosis and therapy. Long non-coding RNAs (lncRNAs) and their downstream regulators are regarded to be implicated in the progression of multiple types of malignancies.
View Article and Find Full Text PDFDecoding aging in the heart via single cell dual omics of non-cardiomyocytes.
iScience
December 2024
Department of Pathology and Laboratory Medicine, University of North Carolina, Chapel Hill, NC 27599, USA.
To understand heart aging at the single-cell level, we employed single-cell dual omics (scRNA-seq and scATAC-seq) in profiling non-myocytes (non-CMs) from young, middle-aged, and elderly mice. Non-CMs, vital in heart development, physiology, and pathology, are understudied compared to cardiomyocytes. Our analysis revealed aging response heterogeneity and its dynamics over time.
View Article and Find Full Text PDFLink between pharyngeal acid reflux episodes and the effectiveness of proton pump inhibitor therapy.
World J Gastroenterol
December 2024
School of Medicine, National Yang Ming Chiao Tung University, Taipei 112, Taiwan.
Background: Diagnosing laryngopharyngeal reflux (LPR) is challenging due to overlapping symptoms. While proton pump inhibitors (PPIs) are commonly prescribed, reliable predictors of their responsiveness are unclear. Reflux monitoring technologies like dual potential of hydrogen (pH) sensors and multichannel intraluminal impedance-pH (MII-pH) could improve diagnosis.
View Article and Find Full Text PDFAbscopal Effect in a Patient With Metastatic Melanoma Receiving Hypofractionated Radiation Therapy and Dual Immune Checkpoint Inhibition: A Case Report.
Cureus
November 2024
Radiation Oncology, Fox Chase Cancer Center, Temple University Hospital, Philadelphia, USA.
Concurrent with the increasing utilization of immune checkpoint inhibitors (ICIs) in melanoma, there has been renewed interest in understanding the potential interplay between radiation therapy (RT) and the immune system. One such phenomenon is the abscopal effect, where localized treatments, such as RT, not only shrink the targeted tumor but also induce shrinkage of untreated tumors elsewhere in the body. Here, we report a case of an abscopal effect in a 63-year-old patient with metastatic melanoma who was progressing on first-line dual ICI therapy but experienced a rapid and durable systemic response following the administration of hypofractionated palliative RT to a large primary melanoma skin tumor.
View Article and Find Full Text PDFDevelopment of a dual PM sampling and direct exposure system incorporated an in vitro air-liquid interface culture method: Application to the northern Thailand haze season.
Environ Pollut
December 2024
Biomedical Engineering Institute, Chiang Mai University, Chiang Mai 50200, Thailand; Biomedical Engineering and Innovation Research Center, Chiang Mai University, Chiang Mai, 50200 Thailand. Electronic address:
Exposure to ambient air pollution is associated with several noncommunicable diseases, and it adversely affects the respiratory system and other organ systems. Several studies have investigated the underlying mechanisms of biological response to air pollutants using conventional techniques, but there is a lack of research on the effects of air pollution at the cellular level. This study developed a dual system that combines PM (particulate matter <2.
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