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[Congenital dysfibrinogenemia: current status and challenges in diagnosis and treatment].
Zhonghua Xue Ye Xue Za Zhi
October 2024
Department of Hematology, Peking Union Medical College Hospital, Chinese Academy of Medical Sciences, Beijing 100730, China.
Congenital dysfibrinogenemia (CDF) is the most common type of congenital fibrinogen disorders, characterized by dysfunctional fibrinogen. Its prevalence is significantly underestimated due to the absence of obvious clinical symptoms in most patients. In addition to bleeding manifestations, patients with CDF may experience thrombotic events or pregnancy-related complications.
View Article and Find Full Text PDFAnalysis of risk factors for trauma-induced coagulopathy in elderly major trauma patients.
World J Emerg Med
January 2024
Department of Emergency Medicine, the Second Affiliated Hospital Zhejiang University School of Medicine / Institute of Emergency Medicine of Zhejiang University, Hangzhou 310009, China.
Article Synopsis
- The study investigates trauma-induced coagulopathy (TIC) in elderly trauma patients, focusing on identifying risk factors associated with increased complications and mortality.
- It analyzed data from 371 patients over five years, noting significant differences between those with TIC and those without in terms of injury severity, serum calcium, fibrinogen, and base excess levels.
- Key risk factors for TIC identified include an injury severity score (ISS) greater than 16, a shock index above 1, and low base excess, highlighting the importance of these metrics in assessing TIC risk in elderly patients.
Serum concentration threshold and risk factors of tigecycline-induced hypofibrinogenaemia in critically ill patients.
J Antimicrob Chemother
January 2025
Department of Pharmacy, Zhongda Hospital, Southeast University, Nanjing 210009, China.
Objectives: Hypofibrinogenaemia is a serious adverse reaction associated with tigecycline (TGC) therapy and may lead to the discontinuation of the treatment. This study aimed to explore the relevant factors of TGC-induced hypofibrinogenaemia and determine the thresholds of serum concentration as a predictive indicator of TGC-induced hypofibrinogenaemia.
Methods: A retrospective single-centre study was conducted on patients with severe infection who were treated with TGC.
Machine learning-based prediction model for hypofibrinogenemia after tigecycline therapy.
BMC Med Inform Decis Mak
October 2024
Pharmacy Department, Sir Run Run Shaw Hospital, School of Medicine, Zhejiang University, Hangzhou, 310020, China.
Background: In clinical practice, the incidence of hypofibrinogenemia (HF) after tigecycline (TGC) treatment significantly exceeds the probability claimed by drug manufacturers.
Objective: We aimed to identify the risk factors for TGC-associated HF and develop prediction and survival models for TGC-associated HF and the timing of TGC-associated HF.
Methods: This single-center retrospective cohort study included 222 patients who were prescribed TGC.
A surface-functionalized whole blood-based dielectric microsensor for assessment of clot firmness in a fibrinolytic environment.
Biosens Bioelectron
January 2025
Department of Electrical, Computer, and Systems Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA; Department of Biomedical Engineering, Case Western Reserve University, Cleveland, OH, 44106, USA. Electronic address:
Accurate assessment of fibrin clot stability can predict bleeding risk in coagulopathic conditions such as thrombocytopenia and hypofibrinogenemia. Hyperfibrinolysis - a clinical phenotype characterized by an accelerated breakdown of the fibrin clot - makes such assessments challenging by obfuscating the effect of hemostatic components including platelets or fibrinogen on clot stability. In this work, we present a biofunctionalized, microfluidic, label-free, electronic biosensor to elicit unique, specific, and differential responses from the multifactorial processes of blood coagulation and fibrinolysis ex vivo.
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