AI Article Synopsis
- * While some studies debate the impact of nicotine on infection severity, this study found that nicotine in drinking water did not affect the health of hACE2 mice.
- * Pre-exposure to nicotine, however, reduced the expression of SARS-CoV-2 RNA and brain damage, suggesting that nicotine-related mechanisms could help mitigate the neurological effects of the virus.*
Article Abstract
Individuals infected by SARS-CoV-2 are at risk of developing neurological-related post-acute disorders. Disputed epidemiological data indicated nicotine may reduce the severity of infection. Here we find exposure to nicotine in drinking water does not alter the moribundity of hACE2 mice. However, pre-exposure to nicotine decreased the likelihood of SARS-CoV-2 RNA expression and pathology in the brain. These results suggest mechanisms involving targets of nicotine could be leveraged to prevent the neurovirulence of SARS-CoV-2.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9898857 | PMC |
| http://dx.doi.org/10.1038/s41598-023-29118-6 | DOI Listing |
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