AI Article Synopsis
- Neuroinflammation is linked to Parkinson's disease (PD), with multiple studies analyzing inflammatory markers in blood and cerebrospinal fluid (CSF) of PD patients compared to controls.
- Data from 152 studies showed increased levels of several inflammatory markers (like IL-6 and TNF-α) and decreased levels of others (like INF-γ) in the PD group, indicating significant inflammation associated with the disease.
- The findings confirm that PD involves altered inflammatory responses both in peripheral blood and CSF, supporting the theory of neuroinflammation's role in PD pathogenesis.
Article Abstract
Neuroinflammation plays a crucial role in the pathogenesis of Parkinson's disease (PD), but controversies persist. Studies reporting concentrations of blood or cerebrospinal fluid (CSF) markers for patients with PD and controls were included and extracted. Pooled Hedges'g was adopted to illustrate comparisons, and covariates were used to explore sources of heterogeneity. Finally, 152 studies were included. Increased IL-6, TNF-α, IL-1β, STNFR1, CRP, CCL2, CX3CL1, and CXCL12 levels and decreased INF-γ and IL-4 levels were noted in the PD group. In addition, increased CSF levels of IL-6, TNF-α, IL-1β, CRP and CCL2 were revealed in patients with PD compared to controls. Consequently, significantly altered levels of inflammatory markers were verified between PD group and control, suggesting that PD is accompanied by inflammatory responses in both the peripheral blood and CSF. This study was registered with PROSPERO, CRD42022349182.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9899271 | PMC |
| http://dx.doi.org/10.1038/s41531-023-00449-5 | DOI Listing |
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