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A platform to map the mind-mitochondria connection and the hallmarks of psychobiology: the MiSBIE study.
Trends Endocrinol Metab
October 2024
Division of Behavioral Medicine, Department of Psychiatry, Columbia University Irving Medical Center, New York, NY, USA; H. Houston Merritt Center for Neuromuscular and Mitochondrial Disorders, Columbia Translational Neuroscience Initiative, Department of Neurology, Columbia University Medical Center, New York, NY, USA; Robert N. Butler Columbia Aging Center, Columbia University Mailman School of Public Health, New York, NY, USA; New York State Psychiatric Institute, New York, NY, USA. Electronic address:
Article Synopsis
- Health is influenced by mitochondrial energy transformation, which plays a crucial role in regulating various body systems that relate to resilience and disease risk throughout life.
- The MiSBIE study aims to explore how mitochondria affect interconnected systems like neuroendocrine, immune, and cognitive functions, focusing on individuals with mitochondrial diseases.
- This research seeks to enhance understanding of mitochondrial diseases, develop new health biomarkers, and better integrate knowledge of the connections between energy processes and overall health.
Both Nuclear and Membrane Estrogen Receptor Alpha Impact the Expression of Estrogen Receptors and Plasticity Markers in the Mouse Hypothalamus and Hippocampus.
Biology (Basel)
April 2023
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY 10065, USA.
Estrogens via estrogen receptor alpha (ERα) genomic and nongenomic signaling can influence plasticity processes in numerous brain regions. Using mice that express nuclear only ERα (NOER) or membrane only ERα (MOER), this study examined the effect of receptor compartmentalization on the paraventricular nucleus of the hypothalamus (PVN) and the hippocampus. The absence of nuclear and membrane ERα expression impacted females but not males in these two brain areas.
View Article and Find Full Text PDFSleep Deprivation and Circadian Disruption Stress, Allostasis, and Allostatic Load.
Sleep Med Clin
June 2022
Department of Psychological and Brain Sciences, Neuroscience and Behavior Program, University of Massachusetts Amherst, Tobin Hall, 135 Hicks Way, Amherst, MA 01003, USA. Electronic address:
Getting a good night's sleep seems a panacea for improving mood and cognition. These subjective impressions are supported by countless studies exploring the impacts of sleep (and sleep loss) on mental health, metabolism, and immune function. Similarly, being "out of phase" with local time, commonly experienced by shift workers of jet-lagged air travelers, demonstrates that there are both neural and physiologic effects of internal circadian (daily) time being misaligned with external environmental time.
View Article and Find Full Text PDFSex and chronic stress alter the distribution of glutamate receptors within rat hippocampal CA3 pyramidal cells following oxycodone conditioned place preference.
Neurobiol Stress
March 2022
Feil Family Brain and Mind Research Institute, Weill Cornell Medicine, 407 East 61st Street, New York, NY, 10065, USA.
Glutamate receptors have a key role in the neurobiology of opioid addiction. Using electron microscopic immunocytochemical methods, this project elucidates how sex and chronic immobilization stress (CIS) impact the redistribution of GluN1 and GluA1 within rat hippocampal CA3 pyramidal cells following oxycodone (Oxy) conditioned place preference (CPP). Four groups of female and male Sprague-Dawley rats subjected to CPP were used: Saline- (Sal) and Oxy-injected (3 mg/kg, I.
View Article and Find Full Text PDFCorticosterone induces discrete epigenetic signatures in the dorsal and ventral hippocampus that depend upon sex and genotype: focus on methylated Nr3c1 gene.
Transl Psychiatry
March 2022
Laboratory of Neuroendocrinology, The Rockefeller University, New York, NY, USA.
The genomic effects of circulating glucocorticoids are particularly relevant in cortico-limbic structures, which express a high concentration of steroid hormone receptors. To date, no studies have investigated genomic differences in hippocampal subregions, namely the dorsal (dHPC) and ventral (vHPC) hippocampus, in preclinical models treated with exogenous glucocorticoids. Chronic oral corticosterone (CORT) in mouse is a pharmacological approach that disrupts the activity of the hypothalamic-pituitary-adrenal axis, increases affective behavior, and induces genomic changes after stress in the HPC of wildtype (WT) mice and mice heterozygous for the gene coding for brain-derived neurotrophic factor Val66Met (hMet), a variant associated with genetic susceptibility to stress.
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