Background: Carboxyhemoglobin (COHb) is considered a biomarker of oxidative stress and previous studies suggest a correlation between its blood level and prematurity complications. Our aim in this study was to assess the correlation between COHb levels and the risk for bronchopulmonary dysplasia (BPD), intraventricular hemorrhage (IVH), and retinopathy of prematurity (ROP).
Methods: We retrospectively studied 178 preterm infants with gestational age of 27.0 ± 1.5 weeks, among which 121 (68 %) had BPD, 43 (24 %) IVH, and 33 (19 %) ROP. COHb levels measured during the first seven days of life were recorded.
Results: Logistic regression analysis showed that higher levels of COHb on the seventh day of life increases the risk for moderate-to-severe BPD (OR 4.552, 95 % Cl 1.220-16.997; P = 0.024), while higher levels of COHb on the fourth day of life increases the risk for grade 2-4 IVH (OR 5.537, 95 % Cl 1.602-19.134; P = 0.007).
Conclusions: COHb measured in the first week of life can contribute to predicting the risk for BPD and IVH, but not for ROP, in very preterm infants. Since COHb can be readily measured, its assessment can be useful in clinical practice for early identification of preterm infants at high risk for oxidative stress related complications.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.cca.2023.117241 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
The development of preterm infants from low socio-economic status families: The combined effects of melatonin, autonomic nervous system maturation and psychosocial factors (ProMote): A study protocol.
PLoS One
January 2025
Department of Neonatology/Neonatal Intensive Care Unit, University Hospital of Heraklion, School of Medicine, University of Crete, Heraklion, Crete, Greece.
Preterm births constitute a major public health issue and a chronic, cross-generational condition globally. Psychological and biological factors interact in a way that women from low socio-economic status (SES) are disproportionally affected by preterm delivery and at increased risk for the development of perinatal mental health problems. Low SES constitutes one of the most evident contributors to poor neurodevelopment of preterm infants.
View Article and Find Full Text PDFNeonatal and Home-Based PT Improves Neurodevelopmental Outcomes of Preterm Infants-A Randomized Clinical Trial.
Pediatr Phys Ther
January 2025
Department of Physical Therapy, Ellmer College of Health Sciences, Macon & Joan Brock Virginia Health Sciences, Old Dominion University, Norfolk, Virginia (Dr Khurana); Department of Pediatrics, Kasturba Medical College, Manipal Academy of Higher Education, Manipal, India (Dr Lewis); School of Exercise Science, Old Dominion University, Norfolk, Virginia (Dr Russell); Sykes Chair of Pediatric Physical Therapy, Health, and Development, University of Southern California, Division of Biokinesiology and Physical Therapy, Los Angeles, California (Dr Dusing); Department of Physiotherapy, Manipal College of Health Professions, Manipal Academy of Higher Education, Manipal, India (Dr Krishna Rao).
Purpose: Investigate the effect of structured neonatal physical therapy program (SNP) on neurodevelopmental outcomes of moderate and late preterm (MLP) infants.
Methods: Sixty MLP infants were randomly allocated to usual care (UC) or SNP. A previous publication reported the effect of neonatal component of SNP at hospital discharge.
Comparison of Transepidermal Water Loss in Preterm Newborns Treated with Two Different Types of Phototherapies.
Adv Skin Wound Care
January 2025
Meryem Aydin, PhD, is Assistant Professor, Faculty of Health Science, Department of Pediatric Nursing, Duzce University, Konuralp, Düzce, Turkey. Serap Balci, PhD, is Associate Professor, Florence Nightingale Nursing Faculty, Department of Pediatric Nursing, Istanbul University-Cerrahpaşa, Istanbul, Turkey.
Objective: To compare transepidermal water loss (TEWL) in preterm newborns treated with two different types of phototherapies.
Methods: In this experimental randomized controlled study, participants were 60 preterm infants aged 30 to 36 weeks' gestation who were admitted to the neonatal ICU of Duzce University Research and Application Center from December 2015 to May 2016. Researchers randomly assigned the newborns to two phototherapy groups: light-emitting diode (LED) and fluorescent phototherapy.
Comparison of Coconut and Sunflower Seed Oils in Improving the Skin Integrity and Weight Gain of Infants in the Neonatal ICU.
Adv Skin Wound Care
January 2025
Öznur Tiryaki, PhD, RN, is Associate Professor, Faculty of Health Sciences, Department of Midwifery, Sakarya University, Sakarya, Turkey. Hamide Zengin, PhD, RN, is Associate Professor, Faculty of Health Science, Department of Pediatric Nursing, Eskişehir Osmangazi University, Eskişehir, Turkey. Also at Sakarya University, Nursan Çınar, PhD, RN, is Professor, Faculty of Health Sciences, Department of Pediatric Nursing; Meltem Karabay, MD, is Associate Professor, Faculty of Medicine, Research and Training Hospital of Sakarya, Division of Neonatology, Department of Pediatrics; İbrahim Caner, MD, is Professor, Faculty of Medicine, Research and Training Hospital of Sakarya, Division of Neonatology, Department of Pediatrics; and Ertuğrul Güçlü, MD, is Professor, Faculty of Medicine, Department of Infectious Diseases and Clinical Microbiology.
Objective: To determine the effects of sunflower seed oil and coconut oil on the skin integrity and weight gain of preterm infants in the neonatal ICU.
Methods: In this randomized controlled trial, 66 preterm neonates (34-37 weeks' gestation) in the neonatal ICU of a training and research hospital were equally divided into three groups: sunflower seed oil, coconut oil, and control. The weights of neonates in all three groups were measured at admission to the neonatal ICU, at discharge, and at 1 month postdischarge.
Living in a bubble with profound difficulties-parents' experiences of extremely preterm survivors.
Acta Paediatr
January 2025
Department of Clinical Neuroscience, Institute of Neuroscience and Physiology, Sahlgrenska Academy, University of Gothenburg, Gothenburg, Sweden.
Aim: To analyse the challenges faced by parents of extremely preterm infants born before 24 weeks of gestation and the potential buffering effect of perceived resources on the family's health continuum.
Methods: The qualitative data were obtained from 70 parents of 70 infants born before 24 weeks of gestation, through open-ended questions in a survey. An inductive content analysis was conducted to identify themes and patterns in the parents' experiences.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!