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Toxicokinetics and toxicodynamics of Ag nanomaterials (NM300K) in the soil environment-impact on Enchytraeus crypticus (Oligochaeta). | LitMetric

AI Article Synopsis

  • - The study investigated the toxicokinetics and toxicodynamics of silver (Ag) from two forms—AgNO and Ag nanoparticle (AgNM300K)—in the soil-dwelling organism Enchytraeus crypticus over a 21-day period.
  • - Results indicated that AgNM300K led to lower internal Ag accumulation and elimination rates compared to AgNO, suggesting it may be less toxic based on internal concentrations despite similar lethal concentrations (LC50).
  • - The research highlights that the timing of toxicity responses is crucial in evaluating the environmental impact of nanomaterials, emphasizing the increased need for careful assessment of their effects.

Article Abstract

Silver (Ag) is one of the most used elements in the nanomaterials (NMs) form, which upon release to the environment can be harmful to organisms. We compared the toxicokinetics (TK) and toxicodynamics (TD) of Ag from AgNO (0, 15, 45, 135, 405 mg Ag/kg soil) and AgNM300K (0, 75, 150, 300, 600, 1200 mg Ag/kg soil) in the model organism Enchytraeus crypticus. Organisms were exposed in LUFA 2.2 soil, and besides body Ag concentrations, survival and reproduction were determined, in a time series (for 21 days). In the soil, the available (CaCl extractable) Ag fraction from Ag NM300K increased from 0 to 21 days but did not consistently change for AgNO. Internal concentrations reached equilibrium in most exposures to both Ag forms. The organisms were able to internalize and eliminate Ag, but less when exposed to Ag NM300K. The overall uptake rate constants for Ag from AgNO and Ag NM300K exposures were 0.05 and 0.06 kg soil/kg organism/day, respectively, the elimination rate constants 0.2 and 0.1 day, respectively. For AgNO the median lethal concentrations decreased steadily with time, while for Ag NM300K they remained constant during the first 10 days of exposure followed by a 2-fold decline in the last 7 days. The 21-d LC50s for both Ag forms were similar but the LC50 (based on internal concentrations) were 63 and 121 mg Ag/kg body DW (Dry Weight) for AgNO and Ag NM300K, respectively, showing higher toxicity of AgNO. These results show the importance of assessing time to toxicity, a relevant factor in toxicity assessment, especially for NMs.

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http://dx.doi.org/10.1016/j.ecoenv.2023.114599DOI Listing

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