AI Article Synopsis
- * Researchers tested 45 hiochi bacteria strains and found that Lentilactobacillus hilgardii H-50 significantly reduces the secretion of key inflammatory markers (TNF-α, IL-1β, IL-6) in mouse immune cells when triggered by LPS.
- * The anti-inflammatory action of L. hilgardii H-50 is linked to its specific surface layer proteins that interact directly with LPS.
Article Abstract
Aims: Certain lactic acid bacteria (LAB) are known to have anti-inflammatory effects; however, hiochi bacteria, which are taxonomically classified as LAB and known to spoil a traditional Japanese alcoholic beverage, have not been studied in the same context. The aim of this study is to investigate the anti-inflammatory effects of hiochi bacteria strains and the underlying mechanisms.
Methods And Results: We screened 45 strains of hiochi bacteria for anti-inflammatory effects and found that Lentilactobacillus hilgardii H-50 strongly inhibits lipopolysaccharide (LPS)-induced secretion of tumor necrosis factor (TNF)-α, interleukin (IL)-1β, and IL-6 in mouse splenocytes. This inhibition is attributed to its specific surface layer proteins (SLPs), which directly bind to LPS.
Conclusions: The L. hilgardii H-50 strain exerts anti-inflammatory effects through its SLPs.
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| http://dx.doi.org/10.1093/jambio/lxad021 | DOI Listing |
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