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Ability and utility of the Physician Well-Being Index to identify distress among Chinese physicians.
Ann Med
December 2025
Department of Psychiatry, National Clinical Research Center for Mental Disorders, and National Center for Mental Disorders, the Second Xiangya Hospital of Central South University, Changsha, Hunan, China.
Background: Despite the high prevalence of mental stress among physicians, reliable screening tools are scarce. This study aimed to evaluate the capability of the Physician Well-Being Index (PWBI) in identifying distress and adverse consequences among Chinese physicians.
Methods: This cross-sectional online survey recruited 2803 physicians from Southern Mainland China snowball sampling between October and December 2020.
Omega-3 index improves upon the pooled cohort equation in predicting risk for CVD.
J Clin Lipidol
February 2025
Fatty Acid Research Institute, Sioux Falls, SD, USA (Drs Tintle, Marchioli, and Harris); Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA (Dr Harris).
Background: Accurate predictive tools are crucial for identifying patients at increased risk for atherosclerotic cardiovascular disease (ASCVD). The Pooled Cohort Equation (PCE) is commonly used to predict 10-year risk for ASCVD, but its accuracy remains imperfect.
Objective: This study examined the extent to which the omega-3 index (O3I; the proportion of eicosapentaenoic acid+docosahexaenoic acid in erythrocyte membranes) improved the predictive capability of PCE.
A Revised Optical Coherence Tomography-Derived Calcium Score to Predict Stent Underexpansion in Severely Calcified Lesions.
JACC Cardiovasc Interv
March 2025
Clinical Trials Center, Cardiovascular Research Foundation, New York, New York, USA; Division of Cardiology, Department of Medicine, Columbia University Medical Center/NewYork-Presbyterian Hospital, New York, New York, USA.
Background: Severe calcification is the morphology most strongly associated with stent underexpansion.
Objectives: The aim of this study was to revise an optical coherence tomography (OCT)-derived calcium score to predict stent underexpansion in severely calcified lesions (angle >270°) using a point-based system.
Methods: A retrospective observational study was conducted in which 250 de novo lesions undergoing OCT-guided stenting, with angiographically visible calcium and optical coherence tomographic maximum superficial calcium angle >270°, not subjected to atherectomy or specialty balloon treatment before stent implantation, were randomly divided into derivation (n = 167) and validation (n = 83) cohorts.
Global Algorithm for the Endovascular Treatment of Chronic Femoropopliteal Lesions: An Interdisciplinary Expert Opinion Statement.
JACC Cardiovasc Interv
March 2025
Department of Cardiology and Vascular Medicine, West German Heart and Vascular Center, University of Duisburg-Essen, Essen, Germany.
A global treatment algorithm was developed for the endovascular revascularization of femoropopliteal lesions and chronic total occlusions, aiming toward a more standardized approach to endovascular treatment in patients with peripheral artery disease. The following steps are proposed. 1) Evaluation of lesion morphology based on preprocedural imaging by Duplex sonography and intravenous ultrasound for selection of lesion preparation tools.
View Article and Find Full Text PDFComputational and molecular insights on non-synonymous SNPs associated with human RAAS genes: Consequences for Hypertension vulnerability.
J Genet Eng Biotechnol
March 2025
Department of Bioinformatics, Pharmacogenomics and CADD Lab, Alagappa University, Karaikudi, Tamil Nadu, India. Electronic address:
Hypertension is the foremost modifiable risk factor for cardiovascular and renal diseases, and overall mortality on a global scale. Genetic variants have the potential to alter an individual's drug responses. In the present study, we employed a comprehensive computational analysis to evaluate the structural and functional implications of deleterious missense variants to examine the influence of RAAS genes such as AT1R, AT2R, and MasR on susceptibility to hypertension.
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