AI Article Synopsis
- This review compares the side effects experienced by patients with advanced melanoma receiving either immune checkpoint inhibitors (ICIs) or targeted therapies (TT).
- It analyzed data from 24 Phase III trials, focusing on adverse events (AEs) reported in at least 10% of patients.
- While ICIs resulted in fewer overall side effects than TT, they were linked to a higher occurrence of long-term or permanent side effects, as opposed to the generally short-term and reversible toxicities associated with TT.
Article Abstract
Introduction: This systematic scoping review compares the toxicities experienced by patients receiving immune checkpoint inhibitors (ICIs) or targeted therapy (TT) for stage III (resected and unresectable) and stage IV melanoma.
Methods: OVID Medline, Embase, and PsycInfo were searched to identify Phase III trials reporting toxicities of FDA-approved ICIs and TT for advanced melanoma. AEs that were reported by ≥ 10% of patients in the evaluated trials were included.
Results: Toxicity profiles of 11208 patients from 24 studies were reviewed. The rate of AEs was lower with ICIs compared to TT. However, ICIs were associated with higher rates of long-term or permanent AEs compared to TT, where toxicities generally were shortterm and reversible with treatment discontinuation.
Conclusion: The toxicity profiles of ICIs and TT vary substantially. Whilst the rate of AEs was lower with ICIs than during TT, it was also associated with higher rates of potentially chronic AEs.
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| http://dx.doi.org/10.1016/j.critrevonc.2023.103919 | DOI Listing |
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