AI Article Synopsis
- Monoclonal gammopathy of renal significance (MGRS) is a group of kidney problems caused by a special type of protein made by certain immune cells, which affects how the kidneys work.
- These kidney issues can be serious and may lead to severe kidney failure, requiring doctors to do a kidney biopsy for a proper diagnosis.
- Treatment requires teamwork between different types of doctors, focusing on the specific protein problem and how badly the kidneys are affected.
Article Abstract
Monoclonal gammopathy of renal significance (MGRS) is a hemato-nephrological term referring to a heterogeneous group of kidney disorders characterized by direct or indirect kidney injury caused by a monoclonal immunoglobulin (MIg) produced by a B cell or plasma cell clone that does not meet current hematologic criteria for therapy. MGRS-associated kidney diseases are diverse and can result in the development of end stage kidney disease (ESKD). The diagnosis is typically made by nephrologists through a kidney biopsy. Many distinct pathologies have been identified and they are classified based on the site or composition of the deposited Mig, or according to histological and ultrastructural findings. Therapy is directed towards the identified underlying clonal population and treatment decisions should be coordinated between hematologists and nephrologists in a multidisciplinary fashion, depend on the type of MGRS, the degree of kidney function impairment and the risk of progression to ESKD.
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| http://dx.doi.org/10.1016/j.critrevonc.2023.103926 | DOI Listing |
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