AI Article Synopsis
- Human brain organoids derived from pluripotent stem cells show potential for brain repair and can mimic structural features of the brain.
- This study reveals that these organoids can integrate into the adult rat visual system, forming connections with the host's retina and other visual regions after transplantation into damaged areas.
- The findings indicate that the transplanted organoid neurons can respond to visual stimuli, suggesting they may restore functional capacity following cortical injuries.
Article Abstract
Brain organoids created from human pluripotent stem cells represent a promising approach for brain repair. They acquire many structural features of the brain and raise the possibility of patient-matched repair. Whether these entities can integrate with host brain networks in the context of the injured adult mammalian brain is not well established. Here, we provide structural and functional evidence that human brain organoids successfully integrate with the adult rat visual system after transplantation into large injury cavities in the visual cortex. Virus-based trans-synaptic tracing reveals a polysynaptic pathway between organoid neurons and the host retina and reciprocal connectivity between the graft and other regions of the visual system. Visual stimulation of host animals elicits responses in organoid neurons, including orientation selectivity. These results demonstrate the ability of human brain organoids to adopt sophisticated function after insertion into large injury cavities, suggesting a translational strategy to restore function after cortical damage.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9926224 | PMC |
| http://dx.doi.org/10.1016/j.stem.2023.01.004 | DOI Listing |
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