The aim of our study was to assess the clinical course, disease duration, functional status dynamics and prevalence of elevated blood sugar values in patients with frozen shoulder (FS). We also tested two other hypotheses: a) Duration of symptoms before the beginning of therapy affects rehabilitation outcome and duration of symptoms. b) Postponed initiation of therapy affects the duration of sick leave.Our prospective study took place at the University Rehabilitation Institute-Republic of Slovenia (URI-RS) between April 2017 and March 2021. The sample comprised 26 patients with FS. We evaluated patients every 3 months for consecutive 2 years with the Disabilities of the Arm, Shoulder and Hand (DASH) questionnaire, the Shoulder Pain and Disability Index (SPADI) and by measuring the shoulder range of motion (ROM).During the first year, there was a statistically significant change in passive ROM, against no improvement in the second year of follow-up. Only one of the patients was a known diabetic, the majority (77 %) of patients had normal blood sugar values, and in the remaining patients, elevated levels were incidental findings. Twelve patients were on sick leave for more than 12 weeks.The study showed that the duration of sick leave did not corelate with time to treatment initiation. It is advisable to perform a fasting blood sugar test in patients with FS.
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http://dx.doi.org/10.5604/01.3001.0016.2320 | DOI Listing |
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology, ISF College of Pharmacy, Ghal Kalan, GT Road, Moga, 142001, Punjab, India.
In examining the enduring consequences of diabetes, recent research has focused on the anticipated outcomes of the condition. Specifically, cognitive impairment has been linked to diabetes mellitus dating back to the discovery of insulin. This study delves into the neuroprotective effects of TZP, i.
View Article and Find Full Text PDFUrol Res Pract
January 2025
Department of Transplantation, Beykoz University, Istanbul, Türkiye.
Objective: Simple renal cysts (SRCs) represent the most frequently occurring type of renal cysts, frequently observed in the elderly population. While generally considered benign, SRCs may sometimes be connected to comorbid conditions such as hypertension, aortic diseases, and renal dysfunction. This research aims to investigate the factors influencing the development of SRCs in kidney donors and the associated risks.
View Article and Find Full Text PDFNat Prod Res
January 2025
Department of Pharmacognosy and Medicinal Plants, Faculty of Pharmacy, Al-Azhar University (Boys), Cairo, Egypt.
The herbal extracts of four traditional plants; namely leaves, fruits leaves, and seeds, were identified for their main constituents using UHPLC/QTOF-MS/MS. Then, a pharmacology-based analysis and molecular docking verification were established targeting the evaluation of each individual herbal extract for their antidiabetic/anti-obesity potential besides their safety. Streptozotocin-induced diabetic rats were used to evaluate antiobesity and insulinotropic effects against insulin (10 U/Kg, IP) and metformin (100 mg/Kg, per oral) as standard regimens.
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January 2025
K Soma, Psychology, The University of British Columbia, Vancouver, V6T 1Z4, Canada.
Maternal diet has long-term effects on offspring brain development and behavior. Sucrose (table sugar) intakes are high in modern diets, but it is not clear how a maternal high-sucrose diet (HSD) affects the offspring. In rats, a maternal HSD (26% of calories from sucrose, which is human-relevant) alters maternal metabolism and brain and also alters adult offspring endocrinology and behavior in a sex-specific manner.
View Article and Find Full Text PDFLife Metab
February 2025
New Cornerstone Science Laboratory, State Key Laboratory of Membrane Biology, Beijing Key Laboratory of Cardiometabolic Molecular Medicine, Institute of Molecular Medicine, National Biomedical Imaging Center, The Beijing Laboratory of Biomedical Imaging, Peking-Tsinghua Center for Life Sciences, School of Future Technology, Peking University, Beijing 100871, China.
Glucose-stimulated insulin release from pancreatic β-cells is critical for maintaining blood glucose homeostasis. An abrupt increase in blood glucose concentration evokes a rapid and transient rise in insulin secretion followed by a prolonged, slower phase. A diminished first phase is one of the earliest indicators of β-cell dysfunction in individuals predisposed to develop type 2 diabetes.
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