The theoretical aspects of employing the infusion methods of examination of CSF time course and viscoresilient properties of the cerebrospinal system (CSS) are discussed. The general formula of changes in the time of intracranial pressure (TIP) after a load is given. Dog experiments showed this formula to reflect sufficiently exactly the behavior of the CSS in a TIP range of 24 to 40 cm H2O. Analysis of the data in the literature and the results of the author's studies allows the conclusion that determination of CSF resorption resistance by the method of infusion under constant pressure with subsequent calculation of the CSS resilience gradient from the curve of TIP reduction makes it possible to avoid the disadvantages of the bolus technique.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Functional abnormalities of the glymphatic system in cognitive disorders.
Neural Regen Res
January 2025
Department of Neurolougy, Zhejiang Hospital, Hangzhou, Zhejiang Province, China.
Various pathological mechanisms represent distinct therapeutic targets for cognitive disorders, but a balance between clearance and production is essential for maintaining the stability of the brain's internal environment. Thus, the glymphatic system may represent a common pathway by which to address cognitive disorders. Using the established model of the glymphatic system as our foundation, this review disentangles and analyzes the components of its clearance mechanism, including the initial inflow of cerebrospinal fluid, the mixing of cerebrospinal fluid with interstitial fluid, and the outflow of the mixed fluid and the clearance.
View Article and Find Full Text PDFBrain aging rejuvenation factors in adults with genetic and sporadic neurodegenerative disease.
Brain Commun
January 2025
Department of Neurology, Memory and Aging Center, University of California, San Francisco, CA 94158, USA.
The largest risk factor for dementia is age. Heterochronic blood exchange studies have uncovered age-related blood factors that demonstrate 'pro-aging' or 'pro-youthful' effects on the mouse brain. The clinical relevance and combined effects of these factors for humans is unclear.
View Article and Find Full Text PDFIodoform in Surgical Practice: A Comprehensive Review of Its Historical Evolution, Clinical Applications, and Safety Profiles.
Cureus
December 2024
Department of Neurosurgery, Hurley Medical Center, Flint, USA.
Iodoform, a halogenated organic compound, has been a cornerstone in surgical practice due to its potent antiseptic and antimicrobial properties. This comprehensive review examines the historical evolution, mechanism of action, clinical applications, and safety profile of iodoform across various surgical disciplines. Historically significant formulations like Whitehead's varnish and bismuth iodoform paraffin paste (BIPP) demonstrated remarkable efficacy in wound healing during the late 19th and early 20th centuries.
View Article and Find Full Text PDFHyaluronic Acid-Based Hybrid Nanoparticles as Promising Carriers for the Intranasal Administration of Dimethyl Fumarate.
Int J Nanomedicine
January 2025
Department of Medicine, Surgery and Pharmacy, University of Sassari, Sassari, Italy.
Purpose: Dimethyl fumarate (DMF), the first-line oral therapy for relapsing-remitting multiple sclerosis, is rapidly metabolized into monomethyl fumarate. The DMF oral administration provokes gastrointestinal discomfort causing treatment withdrawal. The present study aimed to develop an innovative formulation for DMF nasal administration.
View Article and Find Full Text PDFMagnetic Induction Phase Difference for Cerebral Hemorrhage Detection.
Sensors (Basel)
December 2024
Department of Biomedical Engineering, Army Medical University, The Third Military Medical University, Chongqing 400038, China.
Magnetic induction phase shift is a promising technology for the detection of cerebral hemorrhage, owing to its nonradioactive, noninvasive, and real-time detection properties. To enhance the detection sensitivity and linearity, a zero-flow sensor was proposed. The uniform primary magnetic field and its counteraction were achieved.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!