Heat stroke (HS) can cause several physiological changes in the body. In its most severe form, it can cause multi-organ failure including encephalopathy, circulatory shock, liver failure, renal failure, disseminated intravascular coagulation, and rhabdomyolysis among others. HS is a preventable condition; however, it can be life-threatening in severe forms. We present a case of HS in a 54-year-old male, with rapidly progressive multi-organ failure and a fatal outcome along with a brief literature review.
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| http://dx.doi.org/10.7759/cureus.33226 | DOI Listing |
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Overexpression of Parkin promotes the protective effect of mitochondrial autophagy on the lung of rats with exertional heatstroke.
J Intensive Med
January 2025
Department of Critical Care Medicine, The Eighth Medical Center of Chinese PLA General Hospital, Beijing, China.
Background: The roles of the Pink1/Parkin pathway and mitophagy in lung injury during heat stroke remain unclear. In this study, we investigated the role of Pink1/Parkin-mediated mitophagy in acute lung injury (ALI) in rats with exertional heat stroke (EHS).
Methods: Sixty Sprague Dawley rats were randomly divided into control (CON), control + Parkin overexpression (CON + Parkin), EHS, and EHS + Parkin overexpression (EHS + Parkin) groups.
The Role of Key Molecules of Pyroptosis in Liver Damage of Rats With Exertional Heat Stroke.
Gastroenterol Res Pract
January 2025
Department of Hepatobiliary Disease, 900th Hospital of Joint Logistics Support Force, Fuzhou General Clinical Medical College of Fujian Medical University, Fuzhou, Fujian, China.
This study is aimed at investigating the role of key molecular elements involved in pyroptosis in liver injury caused by exertional heat stroke (EHS). We established a model of EHS-induced liver injury in Sprague-Dawley rats, with a control group (receiving no treatment) for comparison and 12 rats in each group. Alanine transaminase (ALT) and aspartate transaminase (AST) levels in the blood were detected.
View Article and Find Full Text PDFHeat Stroke in the Era of Global Warming: A Call for Urgent Action.
Ann Glob Health
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Dow University of Health Sciences, Karachi, Pakistan.
Heat stroke (HS) represents a life‑endangering condition that is due to an imbalance between heat generation and dissipation, owing to exposure to hot environments or strenuous exercise. HS is a medical condition that is gaining increased prevalence throughout the world due to a steady rise in temperature, and massive mortalities have been recorded among vulnerable populations. In 2024, extreme heat waves led to increased cases of HS and related fatalities globally, particularly in Karachi, Pakistan.
View Article and Find Full Text PDFHeat Stroke Warning System Prototype for Athletes: A Pilot Study.
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Department of Sports Science and Sports Development, Faculty of Allied Health Sciences, Thammasat University, Pathumthani 12120, Thailand.
This research has developed a heat stroke warning system prototype for athletes utilizing the following sensors: DHT22, GY-906-BAA MLX90614, MAX30102. The device calculates the heat stroke risk and notifies users. The data is recorded, stored, displayed on a free-access website which graphs body temperature, ambient temperature, humidity, heart rate and heat stroke risk, and provides notifications for athletes engaged in outdoor activities.
View Article and Find Full Text PDFThe Mechanism of Modulation of Cardiac Force by Temperature.
Int J Mol Sci
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PhysioLab, University of Florence, 50019 Sesto Fiorentino, Italy.
In maximally Ca-activated demembranated fibres from the mammalian skeletal muscle, the depression of the force by lowering the temperature below the physiological level (~35 °C) is explained by the reduction of force in the myosin motor. Instead, cooling is reported to not affect the force per motor in Ca-activated cardiac trabeculae from the rat ventricle. Here, the mechanism of the cardiac performance depression by cooling is reinvestigated with fast sarcomere-level mechanics.
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