Influence of highly purified staphylococcal lipase on chemotactic activity of human polymorphonuclear leukocytes (PMN), has been studied. Staphylococcal lipase exhibited both chemotactic and chemokinetic properties. Chemotactic response was stimulated at concentration as low as 10(-9) M and was dose-dependent. Pretreatment of PMN with lipase, strongly enhanced chemotactic response toward casein. At the same time, spontaneous migration of these PMN was inhibited. It has been demonstrated that staphylococcal lipase binds to the leukocyte surface. Several possible mechanisms of lipase-induced chemotactic response of human PMN are discussed.
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