Ag is a radionuclide that can be generated by neutron capture on Pd and whose decay properties and production feasibility make it a potential therapeutic agent against arthritis. Due to the discrepancies of recent published values of the half-life of Ag with previous published works which are not thoroughly documented for detailed experiment procedures and uncertainty budgets evaluation, an independent redetermination of the Ag half-life value is required. In this work, a solid Ag source was prepared and repeatedly measured in a high purity Germanium (HPGe) detector to determine its half-life. In total, more than fifty measurements were performed over a period of 26.3 days, corresponding to ∼3.5 half-lives of Ag. The experimental method and corresponding uncertainty budget are presented. The result of 7.419(15) days is consistent with the recently published value, 7.423(13) days, by Collins et al. and deviates by 0.418% from the currently recommended value 7.45(1) days. A new recommend half-life value of 7.437(7) days was determined utilizing all available experimental values by a power-moderated mean (PMM) method.
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http://dx.doi.org/10.1016/j.apradiso.2023.110689 | DOI Listing |
Curr Rev Musculoskelet Med
January 2025
Banner University of Arizona-Phoenix, 7400 N Dobson Rd, Scottsdale, AZ, 86256, U.S.A..
Purpose Of Review: Meniscectomy alters knee function and known to be associated with an increased incidence of knee arthritis. Several methods and materials have been tried to replicate the function of a meniscus. One is a polycarbonate-urethane synthetic medial meniscus implant labeled as NUsurface.
View Article and Find Full Text PDFNeurogastroenterol Motil
January 2025
Division of Gastroenterology and Hepatology, Mayo Clinic, Rochester, Minnesota, USA.
Background: The carbon-13 spirulina gastric emptying breath test (GEBT) is approved to identify delayed, but not accelerated, gastric emptying (GE). We compared the utility of the GEBT to scintigraphy for diagnosing abnormal GE in patients with diabetes mellitus.
Methods: Twenty-eight patients with diabetes ate a 230-kcal test meal labeled with technetium 99 m and C-spirulina, after which 10 scintigraphic images and breath samples (baseline, 15, 30, 45, 60, 90, 120, 150, 180, 210, and 240 min) were collected on 2 occasions 1 week apart.
Naunyn Schmiedebergs Arch Pharmacol
January 2025
Department of Pharmacology and Toxicology, School of Pharmacy, University of Health and Allied Sciences, Ho, Ghana.
Purpose: Major depressive disorder is one of the most common and burdensome psychiatric disorders worldwide. This study evaluated the anxiolytic- and antidepressant-like activity of three semi-synthetic derivatives of xylopic acid (XA) to identify the most promising derivative based on mechanism(s) of action, in vivo pharmacokinetics and in vitro cytotoxicity.
Methods: The anxiolytic potential and the involvement of GABAergic mechanisms were assessed in the elevated plus-maze and open field tests in mice.
JNCI Cancer Spectr
January 2025
Department of Hematology/Oncology, Kaiser Permanente, San Francisco Medical Center, San Francisco, CA, United States.
Background: Patients with cancer who report social needs have worse quality of life, lower healthcare access, and suboptimal health outcomes. However, screening for social needs does not happen systematically and successful screening tools, strategies, and workflows have seldom been described. The downstream effects of screening including resource navigation have also not been well characterized.
View Article and Find Full Text PDFDrug Dev Ind Pharm
January 2025
Department of Pharmacy, Quaid-i-Azam University, Islamabad 44000, Pakistan.
Objective: The fabrication of furosemide (FSM) with enhanced oral bioavailability and encapsulation was achieved using a nanostructured lipid carriers (NLCs) drug delivery system.: The uniform drug distribution is a barrier due to its low dose. The lipid-based delivery system was selected based on its poor solubility and permeability, limiting its poor partitioning and solubility in water-based polymeric delivery systems.
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