In the past decade, the implementation of immunotherapy with checkpoint inhibitors has determined a major change in the management of oncological patients. The challenges associated to the new therapeutic regimen have promoted adapted criteria for response assessment to interpret imaging findings and atypical patterns of response. Parallel to the new morphological criteria, also fluoro-deoxyglucose positron emission/computed tomography imaging has required novel approaches and specific guidelines on how to perform, interpret, and report the scan in patients with solid tumors under immune checkpoint inhibitors therapy. A summary of the novelties related to the new joint international European Association of Nuclear Medicine (EANM)/Society of Nuclear Medicine and Molecular Imaging (SNMMI)/Australian and New Zealand Society of Nuclear Medicine (ANZSNM) guidelines on immunotherapy is provided herein to elucidate most critical aspects in image interpretation.
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http://dx.doi.org/10.1089/cbr.2022.0091 | DOI Listing |
Circ Cardiovasc Imaging
March 2025
Department of Cardiology, Cardiovascular Institute, Thorax Center, Erasmus MC, Rotterdam, The Netherlands (J.J.S., N.v.d.V., D.M., A.H.).
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View Article and Find Full Text PDFHistol Histopathol
February 2025
Bascom Palmer Eye Institute, University of Miami Miller School of Medicine, Miami, FL, USA.
Canonical and non-canonical Wnt signaling pathways are well-characterized regulators of retinal development. Wnt signaling also promotes neuroprotection and regeneration in adult tissues, including retinal ganglion cell (RGC) survival and axonal regrowth after optic nerve injury. However, it is unknown whether Wnt-dependent neuroprotection after injury in the adult CNS is associated with altered expression of developmental genes.
View Article and Find Full Text PDFInt J Chron Obstruct Pulmon Dis
March 2025
Department of Respiratory Medicine, The second Affiliated Hospital, Hainan Medical University, Haikou, 570100, People's Republic of China.
Background: Chronic obstructive pulmonary disease (COPD) has emerged as a very consequential issue threatening human life and health; therefore, research on its pathogenesis is urgently needed. A prior investigation discovered a significant elevation in the phosphoglycerate mutase 5 (PGAM5) expression in the lung tissue of COPD smoking patients. This rise in expression is closely associated with COPD severity.
View Article and Find Full Text PDFImmune Netw
February 2025
Department of Biomedical Sciences, Seoul National University College of Medicine, Seoul 03080, Korea.
Aromatic amino acid (AAA) metabolites, derived from tryptophan, phenylalanine, and tyrosine through coordinated host and microbial metabolism, have emerged as critical modulators of immune function. We examine the complex journey of AAAs from dietary intake through intestinal absorption and metabolic transformation, highlighting the crucial role of host-microbe metabolic networks in generating diverse immunomodulatory compounds. This review provides a unique integrative perspective by mapping the molecular mechanisms through which these metabolites orchestrate immune responses.
View Article and Find Full Text PDFBackground: Radiation literacy, encompassing the understanding of basic principles, applications, risks, and protective measures related to ionizing radiation, is critical for medical personnel working in jobs that involve the use of radioactive materials or medical imaging. In the context of nuclear emergency preparedness, the level of radiation knowledge among healthcare professionals-such as doctors, nurses, and radiographers-directly influences the effectiveness and safety of emergency responses. This study aims to address this gap by evaluating the radiation knowledge of medical personnel and identifying areas for improvement in profession-specific training programs.
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