AI Article Synopsis
- Multifocal lymphangioendotheliomatosis with thrombocytopenia is a rare disease marked by multiple vascular lesions and low platelet counts (thrombocytopenia) that complicate diagnosis due to varied symptoms.
- A case study of a male infant revealed severe thrombocytopenia linked to local inflammation, along with swollen extremities and soft tissue/bone involvement, but no gastrointestinal bleeding.
- Treatment with sirolimus and prednisolone successfully resolved the thrombocytopenia, and elevated levels of plasma angiopoietin-2 may serve as a helpful biomarker for this condition.
Article Abstract
Multifocal lymphangioendotheliomatosis with thrombocytopenia is a rare disease characterized by progressive multiple vascular lesions and is accompanied by thrombocytopenia. The precise diagnosis of this disease is frequently difficult because of the heterogeneity of the clinical symptoms. We report a case of a male infant who presented with severe thrombocytopenia induced by local inflammation. In addition, enlargement of the extremities with soft tissue and bone involvement without gastrointestinal bleeding was observed. The thrombocytopenia resolved after a combination therapy of sirolimus and prednisolone. Our finding that plasma angiopoietin-2 concentrations reflected the disease status suggests its utility as a biomarker of Multifocal lymphangioendotheliomatosis with thrombocytopenia.
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| http://dx.doi.org/10.1097/MPH.0000000000002597 | DOI Listing |
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