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Advancing Tumor Microenvironment Analysis: A Fluorescence Nanosystem for Caspase-1 Monitoring and Synergistic Therapy.
Anal Chem
March 2025
College of Chemistry, Jilin Province Research Center for Engineering and Technology of Spectral Analytical Instruments, Jilin University, Qianjin Street 2699, Changchun 130012, China.
The lack of precise, real-time analytical tools for monitoring tumor microenvironment changes during treatment hinders advancements in integrated diagnostic and therapeutic platforms. Traditional caspase-3 monitoring strategies are limited by their inability to address drug resistance and newly discovered apoptotic pathways, leading to reduced accuracy and practicality. To overcome these limitations, we developed a fluorescence-based "Trojan horse" nanosystem, PFpR@CM, featuring high-sensitivity Caspase-1 detection, tumor-targeted delivery, and photothermal therapy.
View Article and Find Full Text PDFDose Ranging in Pediatric Drug Development Trials Submitted to the US FDA 2012-2020.
J Clin Pharmacol
March 2025
Office of Clinical Pharmacology, Center for Drug Evaluation and Research, US Food and Drug Administration, Silver Spring, MD, USA.
Dose selection is a critical process within pediatric drug development and dose-ranging studies are integral to establish a reasonable dose. The objective of this analysis was to examine the dose-ranging trials utilized in pediatric drug development and to determine (1) the dose-ranging strategies that were used in all available pediatric dose-ranging studies, (2) the success of achieving pediatric labeling in those submissions to the US Food and Drug Administration, and (3) ethical aspects of providing a prospect of direct benefit to pediatric patients in dose-ranging studies. Of the 275 programs that previously surveyed pediatric drug development programs from 2012 to 2020, it was determined that dose-ranging studies were used for 97 (35.
View Article and Find Full Text PDFDirect Integration of Spent LiMnO with High Voltage Aqueous Zinc-Manganese Redox Flow Batteries as a Practical Upcycling Process.
Small
March 2025
Department of Nanoenergy Engineering, Pusan National University, 50, Busan daehak-ro 63 beon-gil 2, Busan, Geumjeong-gu, 46241, Republic of Korea.
With the explosive growth of lithium-ion batteries (LIBs), research on the recycling of spent batteries is widely conducted. However, conventional processes involve complex procedures, high costs, and environmental issues. This study introduces the electrochemical upcycling of spent LiMnO (LMO) cathode material, incorporating pre-filtration (PF) and pre-reduction (PR) processes to enable its direct application in redox flow batteries (RFBs).
View Article and Find Full Text PDFGenomic and proteomic analyses of Nus-dependent non-lambdoid phages reveal a novel coliphage group prevalent in gut: mEp.
Front Microbiol
February 2025
Unidad de Genética, Hospital General de México "Dr. Eduardo Liceaga", México City, México.
Introduction: Nus-dependent Mexican phages (mEp) were previously isolated from clinical samples of human feces. Approximately 50% corresponded to non-lambdoid temperate phages integrating a single immunity group, namely immunity I (mEp), and these were as prevalent as the lambdoid phages identified in such collection.
Methods: In this work, we present the structural and functional characterization of six representative mEp phages (mEp010, mEp013, mEp021, mEp044, mEp515, and mEp554).
Hyperactivation of fatty acid biosynthesis holds promise as a targeted therapeutic strategy in prostate cancer (PCa). However, inhibiting these enzymes could potentially promote metastatic progression in various other cancers. Herein, we found that depletion of acetyl-CoA carboxylase 1 (encoded by ACACA), the enzyme responsible for the first and rate-limiting step of de novo fatty acid biosynthesis, facilitated epithelial-mesenchymal transition (EMT) and migration of PCa cells.
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