Belantamab mafodotin is a relatively new drug used in the treatment of relapsed or refractory multiple myeloma. Clinical studies have shown promising responses, but ocular toxicity remains a major challenge with dose reduction or therapy discontinuation being the only available treatment option. We report a clinical case of a patient with severe keratopathy under therapy with belantamab. The use of rigid gas-permeable corneal contact lenses led to a major visual improvement and enabled therapy continuation at full dose over several months. Although this strategy may not be suitable for all patients, it provides an additional option for the treatment of ocular toxicity of this promising agent.
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http://dx.doi.org/10.1097/ICO.0000000000003237 | DOI Listing |
Eye Contact Lens
December 2024
Department of Ophthalmology (H.T.), Juntendo University Shizuoka Hospital, Izunokuni, Japan; Department of Ophthalmology (A.M.), St. Marianna University School of Medicine, Kawasaki, Japan; Department of Innovative Visual Science (S.K.), Osaka University Graduate School of Medicine, Osaka, Japan; Department of Ophthalmology (Y.H.), Toho University Faculty of Medicine, Tokyo, Japan; and Japan Contact Lens Society (H.T., A.M., S.K., Y.H.), Osaka, Japan.
This review examines the history of contact lens (CL) care products, particularly focusing on hard contact lenses (HCLs) like those made from polymethyl methacrylate and rigid gas permeable (RGP) materials. Although literature on CL history is extensive, there is limited information on the history of CL care products, especially in Japan. This review uses advertisements from the Journal of the Japan Contact Lens Society from 1959 to 2023 to trace the evolution of these products.
View Article and Find Full Text PDFSci Rep
November 2024
Changsha Aier Eye Hospital, Changsha, 410015, Hunan Province, China.
The purpose of this study is to investigate the improvement in visual acuity when applying Rigid Gas Permeable Contact Lenses (RGPCL) compared to spectacles in patients after surgical treatment for infantile nystagmus syndrome (INS). A total of 33 patients with nystagmus who had nystagmus surgery from October 2020 to July 2021 were enrolled and all were fitted RGPCL. SPSS statistical software was used to analyze the difference between best-corrected visual acuity with spectacle(BCSVA) and best-corrected visual acuity with RGPCL (BCRVA) in these patients.
View Article and Find Full Text PDFCont Lens Anterior Eye
November 2024
Department of Optometry and Vision, Faculty of Optics and Optometry, Universidad Complutense de Madrid, Madrid, Spain; Ocupharm Group Research, Faculty of Optics and Optometry, Universidad Complutense de Madrid, 28037 Madrid, Spain. Electronic address:
Purpose: To analyze the efficacy of different disinfecting methods for contact lenses (CL) against Acanthamoeba castellanii (AC) using quantitative PCR (qPCR) based on RNA detection.
Methods: Three CL materials: rigid gas permeable (RGP), hydrogel (Hy), and silicone hydrogel (SiHy), were contaminated with 1x10 amoebae/ml and incubated for 24 h at 30 °C. After contamination, pre-cleaning steps were performed before using four maintenance solutions based on hydrogen peroxide (HP), sodium hypochlorite (SH), povidone-iodine (PI), and a multipurpose solution (MS).
Cont Lens Anterior Eye
February 2025
Groupe de Recherche Clinique #32, Transplantation et Thérapies Innovantes de la Cornée, Sorbonne Université, Hôpital National des 15-20, Paris, France.
Background: To compare the efficiency of three artificial intelligence (AI) frameworks (Standard Machine Learning (ML), Multi-Layer Perceptron (MLP) and Convolution Neural Networks (CNN)) with a reference method (Mean radius of curvature (K)) to predict the posterior radius of curvature of the best-fitted rigid contact lens (RCBFL) in keratoconus eyes.
Methods: This retrospective study included 197 keratoconus eyes of 135 patients fitted with Rose K2® (Menicon®, Nagoya, Japan) rigid contact lenses with one or more topographies available (MS39®, CSO®, Ferrara, Italy) between January 2020 and September 2022. Two types of topographic data (indices and reconstructed maps from raw data) were used for AI analysis.
Eye Contact Lens
February 2025
Cornea and Contact Lens Unit (C.J.O., S.B.), De Lens Ophthalmic Family and Vision Care Centre, Abuja, Nigeria; Department of Optometry and Visual Science (E.K.-A., P.A.), Kwame Nkrumah University of Science and Technology, Kumasi, Ghana; Centre for Eye Research Ireland (E.K.-A.), Environmental Sustainability and Health Institute, Technological University Dublin, Dublin, Ireland; Permeff Eye Care (P.E.T.), Accra, Ghana; First Vision Eye Care (L.A.A.K.), Kumasi, Ghana; and College of Optometry (P.A.), University of Houston, Houston, TX.
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