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Provider- and Facility-Level Variation in Precancerous Cervical Biopsy Diagnoses. | LitMetric

AI Article Synopsis

  • The study aims to assess the variability in cervical biopsy diagnoses among different colposcopists, pathologists, and laboratory facilities to understand the reproducibility issues in cervical cancer screenings.
  • Researchers analyzed data from over 130,000 patients across various sites within the PROSPR I consortium and found significant diagnostic variation at all levels, with the most notable differences occurring between laboratory facilities.
  • The findings highlight the need for improved consistency in cervical biopsy diagnoses to minimize problems like underdiagnosis, overdiagnosis, and unnecessary treatments.

Article Abstract

Objectives: Reproducibility of cervical biopsy diagnoses is low and may vary based on where the diagnostic test is performed and by whom. Our objective was to measure multilevel variation in diagnoses across colposcopists, pathologists, and laboratory facilities.

Methods: We cross-sectionally examined variation in cervical biopsy diagnoses within the 5 sites of the Population-Based Research Optimizing Screening through Personalized Regimens (PROSPR I) consortium within levels defined by colposcopists, pathologists, and laboratory facilities. Patients aged 18 to 65 years with a colposcopy with biopsy performed were included, with diagnoses categorized as normal, cervical intraepithelial neoplasia grade 1 (CIN1), grade 2 (CIN2), and grade 3 (CIN3). Using Markov Chain Monte-Carlo methods, we fit mixed-effects logistic regression models for biopsy diagnoses and presented median odds ratios (MORs), which reflect the variability within each level. Median odds ratios can be interpreted as the average increased odds a patient would have for a given outcome (e.g., CIN2 or CIN3 vs normal or CIN1) when switching to a provider with higher odds of diagnosing that outcome. The MOR is always 1 or greater, and a value of 1 indicates no variation in outcome for that level, with higher values indicating greater variation.

Results: A total of 130,110 patients were included who received care across 82 laboratory facilities, 2,620 colposcopists, and 489 pathologists. Substantial variation in biopsy diagnoses was found at each level, with the most occurring between laboratory facilities, followed by pathologists and colposcopists. Substantial variation in biopsy diagnoses of CIN2 or CIN3 (vs normal or CIN1) was present between laboratory facilities (MOR: 1.26; 95% credible interval = 1.19-1.36).

Conclusions: Improving consistency in cervical biopsy diagnoses is needed to reduce underdiagnosis, overdiagnosis, and unnecessary treatment resulting from variation in cervical biopsy diagnoses.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10038855PMC
http://dx.doi.org/10.1097/LGT.0000000000000721DOI Listing

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