Controlling DNA nanodevices with light-switchable buffers.

Chem Commun (Camb)

Institut des Sciences et Ingénierie Chimiques École Polytechnique Fédérale de Lausanne (EPFL), 1015 Lausanne, Switzerland.

Published: February 2023

Control over synthetic DNA-based nanodevices can be achieved with a variety of physical and chemical stimuli. Actuation with light, however, is as advantageous as difficult to implement without modifying DNA strands with photo-switchable groups. Herein, we show that DNA nanodevices can be controlled using visible light in photo-switchable aqueous buffer solutions in a reversible and highly programmable fashion. The strategy presented here is non-invasive and allows the remote control with visible light of complex operations of DNA-based nanodevices such as the reversible release/loading of cargo molecules.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9933455PMC
http://dx.doi.org/10.1039/d2cc06525hDOI Listing

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