AI Article Synopsis
- Somatic cell reprogramming (SCR) is a process that turns special adult cells into more versatile cells that can become different types of cells in the body.
- This involves studying how certain changes in the cell's DNA and its structure help the cells gain new abilities.
- The review looks into various things that happen when cells are reprogrammed, like modifications to DNA and proteins, which could help scientists improve these techniques for better results in the future.
Article Abstract
Somatic cell reprogramming (SCR) is the conversion of differentiated somatic cells into totipotent or pluripotent cells through a variety of methods. Somatic cell reprogramming also provides a platform to investigate the role of chromatin-based factors in establishing and maintaining totipotency or pluripotency, since high expression of totipotency- or pluripotency-related genes usually require an active chromatin state. Several studies in plants or mammals have recently shed light on the molecular mechanisms by which epigenetic modifications regulate the expression of totipotency or pluripotency genes by altering their chromatin states. In this review, we present a comprehensive overview of the dynamic changes in epigenetic modifications and chromatin states during reprogramming from somatic cells to totipotent or pluripotent cells. In addition, we illustrate the potential role of DNA methylation, histone modifications, histone variants, and chromatin remodeling during somatic cell reprogramming, which will pave the way to developing reliable strategies for efficient cellular reprogramming.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9884706 | PMC |
| http://dx.doi.org/10.3389/fcell.2023.1097780 | DOI Listing |
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