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http://dx.doi.org/10.34197/ats-scholar.2022-0071CM | DOI Listing |
Sleep
January 2025
Sleep Disorders Centers, Department of Neurology, University of Michigan, Ann Arbor, MI, USA.
J Chem Theory Comput
January 2025
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno, Czech Republic.
Molecular dynamics (MD) simulations are an important and well-established tool for investigating RNA structural dynamics, but their accuracy relies heavily on the quality of the employed force field (). In this work, we present a comprehensive evaluation of widely used pair-additive and polarizable RNA s using the challenging UUCG tetraloop (TL) benchmark system. Extensive standard MD simulations, initiated from the NMR structure of the 14-mer UUCG TL, revealed that most s did not maintain the native state, instead favoring alternative loop conformations.
View Article and Find Full Text PDFMol Plant Microbe Interact
January 2025
Max Planck Institute for Biology Tübingen, Max-Planck Ring 5, Tuebingen, Germany, 72076;
Filamentous plant pathogens pose a severe threat to food security. Current estimates suggest up to 23% yield losses to pre- and post-harvest diseases and these losses are projected to increase due to climate change (Singh et al. 2023; Chaloner et al.
View Article and Find Full Text PDFNed Tijdschr Geneeskd
January 2025
Integraal Kankercentrum Nederland (IKNL), Utrecht.
Unlabelled: The number of individuals with advanced cancer is increasing, making palliative care more important. However, there is limited knowledge in the Netherlands about the quality of care received by patients in the palliative phase. This is why the Netherlands comprehensive cancer organization (IKNL) started the 'eQuiPe study' to understand the experienced quality of care and quality of life of patients with advanced cancer and their relatives to further improve palliative care.
View Article and Find Full Text PDFBr J Psychiatry
January 2025
Institute for Mental and Physical Health and Clinical Translation (IMPACT), School of Medicine, Deakin University, Geelong, Australia.
A quirky truth is that the oldest biomarker findings are largely metabolic. These had minimal impact on contemporary thought and research and were largely ignored. They have been rediscovered and validated almost 100 years later, informing our understanding of neurobiology and medical comorbidity and spurring contemporary treatment discovery efforts.
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