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Anti-CD4 monoclonal antibody prevents chronic graft-versus-host disease in mice by inducing immune tolerance of CD8 T cells and alleviating thymus injury.
Front Immunol
January 2025
Department of Hematology, Changhai Hospital, The Second Military Medical University, Shanghai, China.
Background: Chronic graft-versus-host disease (cGVHD) manifests with characteristics of autoimmune disease with organs attacked by pathogenic helper T cells. Recent studies have highlighted the role of T cells in cGVHD pathogenesis. Due to limited understanding of underlying mechanisms, preventing cGVHD after allogenic hematopoietic cell transplantation (HCT) has become a major challenge.
View Article and Find Full Text PDFHodgkin lymphoma in pre-existing thymoma: a case report.
Ann Med Surg (Lond)
December 2024
Department of Pathology, King Hussein Cancer Center, Amman, Jordan.
Introduction: Thymus is a primary lymphoid organ which has an important role in humoral and cellular immunity. It can be a site for various neoplasms including thymomas.
Case Presentation: The authors report a case of a 55-year-old patient presenting with weight loss, night sweats and sensation of heat.
Effects of shallot () powder supplementation on growth, intestinal morphology, immune stimulation, and intestinal bacteria in broiler chickens.
Vet World
October 2024
Division of Veterinary Public Health, Faculty of Veterinary Medicine, Khon Kaen University, Khon Kaen, 40002, Thailand.
Background And Aim: Antimicrobial resistance in poultry farms is a significant global public health concern that has led farmers to explore alternative antibiotics, such as prebiotics in poultry production. This study aimed to examine the antimicrobial activity of ethanolic shallot extract (ESE) and the effects of adding shallot powder (SP) to broiler feed on broiler growth, immune response to Newcastle disease virus (NDV) vaccination, and gastrointestinal tract bacteria.
Materials And Methods: We determined the antimicrobial effects of ESE against O157:H7 (EOH) and TISTR 2365 (L2365) using the agar well diffusion method.
Thymic stromal lymphopoietin signaling in B cells from progenitors to plasma cells.
J Leukoc Biol
October 2024
Center for Fundamental Immunology, Benaroya Research Institute, Seattle, Washington 98101, United States.
Article Synopsis
- Thymic stromal lymphopoietin (TSLP) is a key cytokine involved in promoting type 2 immune responses at barrier tissues, but its effects on B cell diversity are not well understood.
- The text discusses important findings regarding TSLP's role in different stages of B cell development and its contribution to B cell-mediated immune diseases.
- It also mentions the potential of new TSLP-blocking biologics to help regulate B cell responses and improve humoral immunity.
Immunomodulatory effects and multi-omics analysis of Codonopsis Pilosula Extract in septic rats.
J Ethnopharmacol
January 2025
The College of Life Sciences, Northwest University, Xi'an, Shaanxi, 710069, PR China. Electronic address:
Ethnopharmacological Relevance: Codonopsis Pilosula (CP), as a well-known traditional Chinese medicine (TCM) with medicinal and edible herb, is one of the most representative tonic Chinese herbal medicine. It has been widely used for regulating immune function with hardly any adverse effects in clinical practice.
Aim Of The Study: This study aimed to elucidate the immunomodulatory effect and to explore probable mechanism of Codonopsis Pilosula Extract (CPE) in septic rats.
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