Natural and social systems exhibit complex behavior reflecting their rich dynamics, whose governing laws are not fully known. This study develops a unified data-driven approach to estimate predictability of such systems when several independent realizations of the system's evolution are available. If the underlying dynamics are quasi-linear, the signal associated with the variable external factors, or forcings, can be estimated as the ensemble mean; this estimation can be optimized by filtering out the part of the variability with a low ensemble-mean-signal-to-residual-noise ratio. The dynamics of the residual internal variability is then encapsulated in an optimal, in a Bayesian sense, linear stochastic model able to predict the observed behavior. This model's self-forecast covariance matrices define a basis of patterns (directions) associated with the maximum forecast skill. Projecting the observed evolution onto these patterns produces the corresponding component time series. These ideas are illustrated by applying the proposed analysis technique to (1) ensemble data of regional sea-surface temperature evolution in the tropical Pacific generated by a state-of-the-art climate model and (2) consumer-spending records across multiple regions of the Russian Federation. These examples map out a range of possible solutions-from a solution characterized by a low-dimensional forced signal and a rich spectrum of predictable internal modes (1)-to the one in which the forced signal is extremely complex, but the number of predictable internal modes is limited (2). In each case, the proposed decompositions offer clues into the underlying dynamical processes, underscoring the usefulness of the proposed framework.
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http://dx.doi.org/10.1063/5.0135506 | DOI Listing |
Chem Biol Drug Des
January 2025
College of Pharmacology Sciences, Zhejiang University of Technology, Hangzhou, People's Republic of China.
Depression is a mental health disorder and is the fourth most prevalent disease. Previous studies have suggested that statins are involved in the reduction of neuroinflammation. However, the potential mechanism for this relationship is unclear.
View Article and Find Full Text PDFCureus
December 2024
School of Allied Health Sciences, Manav Rachna International Institute of Research and Studies, Faridabad, IND.
Introduction: Sleep deprivation (SD), stemming from a myriad of aetiologies, is a prevalent health condition frequently overlooked. It typically impairs memory consolidation and synaptic plasticity, potentially through neuroinflammatory mechanisms and adenosinergic signalling. It is still unclear whether the adenosine A1 receptor (A1R) modulates SD-induced neurological deficits in the hippocampus.
View Article and Find Full Text PDFCategorization is an essential task for sensory perception. Individuals learn category labels using a variety of strategies to ensure that sensory signals, such as sounds or images, can be assigned to proper categories. Categories are often learned on the basis of extreme examples, and the boundary between categories can differ among individuals.
View Article and Find Full Text PDFBrain Behav
January 2025
School of Psychology, Shandong Second Medical University, Weifang, Shandong, People's Republic of China.
Background: Post-traumatic stress disorder (PTSD) is a complex psychiatric condition that emerges following exposure to trauma and significantly affects daily functioning. Current research is focused on identifying effective treatments for PTSD. Advances in bioinformatics provide opportunities to elucidate the underlying mechanisms of PTSD.
View Article and Find Full Text PDFProg Neuropsychopharmacol Biol Psychiatry
January 2025
Health Management Center, The Third Xiangya Hospital of Central South University, Changsha, China; Department of Cardiology, The Third Xiangya Hospital of Central South University, Changsha, China. Electronic address:
The study investigates how Sphingosine-1-phosphate receptor 3 (S1PR3) and the Chronic Unpredictable Mild Stress (CUMS) affects depression-like behaviors. The S1P/S1PR3 signaling pathway is known to play a role in mood regulation, but it is not yet fully understood how it is connected to depression. This study looks to further explore this topic.
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