AI Article Synopsis

  • There is a current shortage of pediatric multivisceral organ donors, leading to long wait times and increased mortality for children needing transplants.
  • The study discusses a successful case of transplanting multivisceral organs from a donor after cardiac death to a 13-month-old recipient, utilizing techniques like normothermic regional perfusion to minimize damage.
  • The patient showed successful recovery and was discharged two months post-transplant, highlighting a potential solution to decreasing waitlist times for pediatric patients.

Article Abstract

The current shortage of pediatric multivisceral donors accounts for the long time and mortality on the waiting list of pediatric patients. The use of donors after cardiac death, especially after the outbreak of normothermic regional perfusion, has increased in recent years for all solid organs except the intestine, mainly because of its higher susceptibility to ischemia-reperfusion injury. We present the first literature case of multivisceral donors after cardiac death transplantation in a 13-month-old recipient from a 2.5-month-old donor. Once exitus was certified, an extracorporeal membrane oxygenation circuit was established, cannulating the aorta and infrarenal vena cava, while the supra-aortic branches were clamped. The abdominal organs completely recovered from ischemia through normothermic regional perfusion (extracorporeal membrane oxygenation initially and beating heart later). After perfusion with the preservation solution, the multivisceral graft was uneventfully implanted. Two months later, the patient was discharged without any complications. This case demonstrates the possibility of reducing the time spent on the waiting list for these patients.

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Source
http://dx.doi.org/10.1016/j.ajt.2022.12.021DOI Listing

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