AI Article Synopsis
- Mucin-domain glycoproteins are complex proteins with extensive O-glycosylation, playing significant roles in both biochemical and biophysical processes in the body.
- Their abnormal expression and glycosylation patterns are linked to various cancers, highlighting their importance in cancer research, although they remain poorly understood within cancer glycobiology.
- The review discusses methods for studying these proteins and introduces new tools designed to analyze mucin-domain glycoproteins, aiming to improve our understanding of their role in cancer and to aid in developing future cancer treatments.
Article Abstract
Mucin-domain glycoproteins are highly O-glycosylated cell surface and secreted proteins that serve as both biochemical and biophysical modulators. Aberrant expression and glycosylation of mucins are known hallmarks in numerous malignancies, yet mucin-domain glycoproteins remain enigmatic in the broad landscape of cancer glycobiology. Here we review the multifaceted roles of mucins in cancer through the lens of the analytical and biochemical methods used to study them. We also describe a collection of emerging tools that are specifically equipped to characterize mucin-domain glycoproteins in complex biological backgrounds. These approaches are poised to further elucidate how mucin biology can be understood and subsequently targeted for the next generation of cancer therapeutics.
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Source |
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10582998 | PMC |
| http://dx.doi.org/10.1016/bs.acr.2022.09.001 | DOI Listing |
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