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Establishing Outcome Parameters for Helicopter Emergency Medical Services Research in The Netherlands: Results of a Mixed-Methods Delphi Consensus Study.
Prehosp Emerg Care
October 2024
Trauma Research Unit Department of Surgery, Erasmus MC, University Medical Center Rotterdam, Rotterdam, The Netherlands.
Objectives: Physician staffed Helicopter Emergency Medical Services (P-HEMS) care in the Netherlands has transitioned from predominantly trauma management to handling a variety of medical conditions. Relevant outcome parameters for Dutch P-HEMS research have not been previously defined. National consensus was sought to identify relevant long term patient outcome parameters, process outcome parameters and performance outcome parameters for Dutch P-HEMS care.
View Article and Find Full Text PDFHarnessing nature's catalysts: Advances in enzymatic alkene cleavage.
J Biotechnol
November 2024
TU Wien, Institute of Applied Synthetic Chemistry, Getreidemarkt 9, 163-OC, Vienna 1060, Austria. Electronic address:
Double bonds are prevalent in various substrates and renewable feedstocks, and their cleavage typically necessitates harsh reaction conditions involving high temperatures, organic solvents, and hazardous catalysts such as heavy metals or ozone. This review explores the sustainable enzymatic alternatives developed by nature for alkene cleavage. It provides a comprehensive overview of alkene-cleaving enzymes, detailing their mechanisms, substrate specificities, and applications.
View Article and Find Full Text PDFVentilation during cardiopulmonary resuscitation: A narrative review.
Resuscitation
October 2024
Amsterdam UMC location Vrije Universiteit Amsterdam, Anesthesiology, De Boelelaan 1117, Amsterdam, the Netherlands; Amsterdam Public Health, Quality of Care, Amsterdam, the Netherlands.
Article Synopsis
- Ventilation is really important during CPR because it helps get oxygen into the body, but there are still many questions about how to do it best.
- This review talks about the problems faced when trying to ventilate someone during cardiac arrest and what we need to know about how to keep their airways open and give the right amount of air.
- It also looks at tools that can help with breathing during CPR and suggests things we should study more in the future to improve CPR techniques.
Youth Crisis: The Current State and Future Directions.
Psychiatr Clin North Am
September 2024
Innovations Institute, University of Connecticut School of Social Work, 38 Prospect Street, Hartford, CT 06103, USA.
The number of children and youth experiencing behavioral health crisis in the United States is substantially increasing. Currently, there are shortages to home-based and community-based services as well as psychiatric outpatient and inpatient pediatric care, leading to high emergency department utilization. This article introduces a proposed crisis continuum of care, highlights existing evidence, and provides opportunities for further research and advocacy.
View Article and Find Full Text PDFDiscovery of a monoclonal, high-affinity CD8 T-cell clone following natural hepatitis C virus infection.
Immunol Cell Biol
August 2024
School of Biomedical Sciences, Faculty of Health and Medicine, UNSW Sydney, Sydney, NSW, Australia.
CD8 T cells recognizing their cognate antigen are typically recruited as a polyclonal population consisting of multiple clonotypes with varying T-cell receptor (TCR) affinity to the target peptide-major histocompatibility complex (pMHC) complex. Advances in single-cell sequencing have increased accessibility toward identifying TCRs with matched antigens. Here we present the discovery of a monoclonal CD8 T-cell population with specificity for a hepatitis C virus (HCV)-derived human leukocyte antigen (HLA) class I epitope (HLA-B*07:02 GPRLGVRAT) which was isolated directly ex vivo from an individual with an episode of acutely resolved HCV infection.
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