AI Article Synopsis
- Finding the right mix of how to safely reduce the immune system's activity in severe TAFRO syndrome can be tough!
- A 60-year-old man with a serious case of TAFRO syndrome got better after receiving special medications, even though he had a virus!
- The study looked at 14 cases and found that while everyone improved, recovery from low blood platelets (thrombocytopenia) was slow, but all patients on dialysis were able to stop it successfully!
Article Abstract
Finding the ideal balance between efficacy and safety of immunosuppression is challenging, particularly in cases of severe TAFRO syndrome. We herein report a 60-year-old man diagnosed with grade 5 TAFRO syndrome mimicking hepatorenal syndrome that was successfully treated by glucocorticoid, tocilizumab, and cyclosporin despite virus infection. Furthermore, by examining 14 peer-reviewed remission cases, we revealed that the recovery periods among inflammation, renal dysfunction, and thrombocytopenia were quite different, with recovery from thrombocytopenia notably slow. All patients requiring dialysis were successfully withdrawn from dialysis, and the reversibility from kidney injury was good. This clinical information will help clinicians plan treatments and tailor the intensity of immunosuppression.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10569924 | PMC |
| http://dx.doi.org/10.2169/internalmedicine.1178-22 | DOI Listing |
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