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Ernst Bertner: A Surgeon with Prescient Vision for the Largest Medical Center in the World.
Ann Surg Oncol
May 2024
Department of Surgical Oncology, University of Texas MD Anderson Cancer Center, Houston, TX, USA.
More than 75 years ago, surgeon Ernst Bertner envisioned the Texas Medical Center (TMC) as "breathtaking in the scope and breadth of its conception," that would be "one of the largest in the world"; a gigantic medical enterprise that would "attract the greatest scientists of the world" and would combine patient care, research, and education, on a scale that was "second to none." During the next 3 years, Bertner accomplished important pieces of the Herculean task to bring onto the campus 11 major buildings, including the University of Texas MD Anderson Hospital for Cancer Research, for which he was the interim director. This was an extraordinary accomplishment because at the outset he had only a strategic plan, the deed to 134 acres of forest, and financial support from the MD Anderson Foundation! Bertner further forecasted world-class clinical and educational programs in the TMC, stating: "We envision the time when the Medical Center will become a great magnet, drawing leaders in education, medicine, and dental professions.
View Article and Find Full Text PDFA Breathtaking Discovery.
N Engl J Med
February 2023
From the Departments of Medicine (J.C.F., J.J.R., B.D.L., J.L.) and Pathology (Z.F.W.), Brigham and Women's Hospital, Boston.
Analyzing RNA posttranscriptional modifications to decipher the epitranscriptomic code.
Mass Spectrom Rev
November 2023
Department of Chemistry, University of Connecticut, Storrs, Connecticut, USA.
The discovery of RNA silencing has revealed that non-protein-coding sequences (ncRNAs) can cover essential roles in regulatory networks and their malfunction may result in severe consequences on human health. These findings have prompted a general reassessment of the significance of RNA as a key player in cellular processes. This reassessment, however, will not be complete without a greater understanding of the distribution and function of the over 170 variants of the canonical ribonucleotides, which contribute to the breathtaking structural diversity of natural RNA.
View Article and Find Full Text PDFFurther developments of -unsaturated -ketoesters as versatile synthons in asymmetric catalysis.
iScience
March 2022
Green Catalysis Center, and College of Chemistry, Zhengzhou University, Zhengzhou, Henan 450001, China.
-Unsaturated -ketoesters prove to be versatile organic synthons participating in diverse catalytic asymmetric transformations with the breathtaking development of organo-catalysis, new catalytic systems including ingenious chiral ligands as well as Lewis acid cations. The highly efficient creation of stereogenic centers with excellent enantioselectivity is not a surprise, but owes to the bidentate coordination of its unique 1,2-dicarbonyl motif to artful chiral messenger, establishing a rigid system for the precise chiral-identification of the attack. In the past five years, various reaction modes of -unsaturated -ketoesters have been developed, involving their multiple reaction sites, such as the carbon-carbon double bond (C=C), the carbonyl group (C=O), the entire C=C-C=O fragment, and the ester group.
View Article and Find Full Text PDFCancer T-cell therapy: building the foundation for a cure.
F1000Res
April 2021
A2 Biotherapeutics, Agoura Hills, California, 91301, USA.
T-cell cancer therapy is a clinical field flush with opportunity. It is part of the revolution in immuno-oncology, most apparent in the dramatic clinical success of PD-1/CTLA-4 antibodies and chimeric antigen receptor T-cells (CAR-Ts) to cure certain melanomas and lymphomas, respectively. Therapeutics based on T cells ultimately hold more promise because of their capacity to carry out complex behaviors and their ease of modification via genetic engineering.
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