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A Trivalent Live Vaccine Elicits Cross-Species Protection Against Acute Otitis Media in a Murine Model.
Vaccines (Basel)
December 2024
Department of Host-Microbe Interactions, St. Jude Children's Research Hospital, Memphis, TN 38105, USA.
: Acute otitis media (AOM) is a common pediatric infection worldwide and is the primary basis for pediatric primary care visits and antibiotic prescriptions in children. Current licensed vaccines have been incompletely ineffective at reducing the global burden of AOM, underscoring a major unmet medical need. The complex etiology of AOM presents additional challenges for vaccine development, as it can stem from multiple bacterial species including , , and .
View Article and Find Full Text PDFBayesian Architecture for Predictive Monitoring of Unbalance Faults in a Turbine Rotor-Bearing System.
Sensors (Basel)
December 2024
Department of Mechanical Engineering, Ming Chi University of Technology, New Taipei City 24301, Taiwan.
Unbalance faults are among the common causes of interruptions and unexpected failures in rotary systems. Therefore, monitoring unbalance faults is essential for predictive maintenance. While conventional time-invariant mathematical models can assess the impact of these faults, they often rely on proper assumptions of system factors like bearing stiffness and damping characteristics.
View Article and Find Full Text PDFPopulation Pharmacokinetic and Pharmacodynamic Study of Palbociclib in Children and Young Adults with Recurrent, Progressive, or Refractory Brain Tumors.
Pharmaceutics
November 2024
Department of Pharmacy and Pharmaceutical Sciences, St. Jude Children's Research Hospital, 262 Danny Thomas Place, Memphis, TN 38105, USA.
Palbociclib, an oral CDK 4/6 inhibitor, was evaluated in a Pediatric Brain Tumor Consortium (PBTC) phase 1 (NCT02255461; PBTC-042) study to treat children and young adults with recurrent, progressive, or refractory brain tumors. The objectives of this study were to characterize the palbociclib population pharmacokinetics in children enrolled on PBTC-042, to conduct a population pharmacodynamic analysis in this patient population, and to perform a simulation study to assess the role of palbociclib exposure on neutropenia and thrombocytopenia. The palbociclib population pharmacokinetics and pharmacodynamics were characterized in this patient population (n = 34 patients; 4.
View Article and Find Full Text PDFUnexpected Genetic Diversity of Nostocales (Cyanobacteria) Isolated from the Phyllosphere of the Laurel Forests in the Canary Islands (Spain).
Microorganisms
December 2024
Integrative Bioinformatics, Department of Plant Microbe Interactions, Max Planck Institute for Plant Breeding Research, 50829 Cologne, Germany.
A total of 96 strains of Nostocales (Cyanobacteria) were established from the phyllosphere of the laurel forests in the Canary Islands (Spain) and the Azores (Portugal) using enrichment media lacking combined nitrogen. The strains were characterized by light microscopy and SSU rRNA gene comparisons. Morphologically, most strains belonged to two different morphotypes, termed "-type" and "-type".
View Article and Find Full Text PDFRhizosphere Shifts: Reduced Fungal Diversity and Microbial Community Functionality Enhance Plant Adaptation in Continuous Cropping Systems.
Microorganisms
November 2024
Medicinal Plants Research Institute, Yunnan Academy of Agricultural Sciences, No. 2238 Beijing Road, Kunming 650221, China.
Continuous cropping problems constitute threats to perennial plant health and survival. Soil conditioners have the potential to enhance plant disease resistance in continuous cropping systems. However, how microbes and metabolites of the rhizosphere respond to soil conditioner addition remains largely unknown, but this knowledge is paramount to providing innovative strategies to enhance plant adaptation in continuous cropping systems.
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