[Dermatology - Update on systemic treatments for locally advanced and/or metastatic cutaneous squamous cell carcinoma].

Cutaneous squamous cell carcinoma (cSCC) is a common skin malignancy successfully treated by surgery in most patients. Locally advanced (la) and/or metastatic (m) cSCC require systemic treatments to either achieve complete remission or local control before subsequent surgery or radiotherapy. Recently, monoclonal antibodies against programmed cell death protein-1 (PD-1) have proven to be effective in several la/m cSCC treatment trials, with response rates up to 45 % and a one-year progression-free survival up to 55 %. Very recently, the use of anti-PD-1 as a neoadjuvant therapy was evaluated and resulted in a pathological response in almost two-thirds of tumors subsequently removed.