AI Article Synopsis
- Researchers are developing a method called pretargeted click chemistry to diagnose Alzheimer's disease using modified antibodies specific for amyloid-β.
- They created two bis(thiosemicarbazone) compounds with tetrazine groups, which were then labeled with copper-64, a radioactive isotope.
- The copper-64 complexes quickly react with the modified antibodies in a bioorthogonal reaction, allowing them to effectively cross the blood-brain barrier in mice for potential diagnostic purposes.
Article Abstract
With the aim of developing the concept of pretargeted click chemistry for the diagnosis of Alzheimer's disease two antibodies specific for amyloid-β were modified to incorporate -cyclooctene functional groups. Two bis(thiosemicarbazone) compounds with pendant 1,2,4,5-tetrazine functional groups were prepared and radiolabelled with positron emitting copper-64. The new copper-64 complexes rapidly react with the -cyclooctene functionalized antibodies in a bioorthogonal click reaction and cross the blood-brain barrier in mice.
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| http://dx.doi.org/10.1039/d2cc06850h | DOI Listing |
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