AI Article Synopsis
- Researchers have developed a unique nanocarrier that imitates a virus and can adapt its surface properties for better drug delivery.
- This nanocarrier has a rough interior but is initially covered by a polymer that masks its roughness to avoid unwanted interactions in the body.
- In acidic environments, like tumors, the polymer layer disappears, revealing the rough surface to improve the nanocarrier's retention and absorption in tumor tissues, leading to better treatment outcomes.
Article Abstract
Due to non-specific strong nano-bio interactions, it is difficult for nanocarriers with permanent rough surface to cross multiple biological barriers to realize efficient drug delivery. Herein, a camouflaged virus-like-nanocarrier with a transformable rough surface is reported, which is composed by an interior virus-like mesoporous SiO nanoparticle with a rough surface (vSiO ) and an exterior acid-responsive polymer. Under normal physiological pH condition, the spikes on vSiO are hidden by the polymer shell, and the non-specific strong nano-bio interactions are effectively inhibited. While in the acidic tumor microenvironment, the nanocarrier sheds the polymer camouflage to re-expose its rough surface. So, the retention ability and endocytosis efficiency of the nanocarrier are great improved. Owing to it's the dynamically variable rough surface, the rationally designed nanocarrier exhibits extended blood-circulation-time and enhanced tumor accumulation.
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| http://dx.doi.org/10.1002/anie.202216188 | DOI Listing |
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