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Nascent chain-mediated translation regulation in bacteria: translation arrest and intrinsic ribosome destabilization. | LitMetric

Nascent chain-mediated translation regulation in bacteria: translation arrest and intrinsic ribosome destabilization.

J Biochem

Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, S2-19, Nagatsuta 4259, Midori-ku, Yokohama 226-8503, Japan.

Published: March 2023

AI Article Synopsis

Article Abstract

Proteins that exsert physiological functions during being translated have been discovered from prokaryotes to eukaryotes. These proteins, also called regulatory nascent chains, are common in interacting co-translationally with the ribosomes to stall them. In most cases, such a translational arrest is induced or released in response to changes in the intracellular environment. Cells take advantage of such an environmental sensitivity as a sensor to feedback-regulate gene expression. Recent studies reveal that certain nascent chains could also destabilize the translating ribosomes, leading to stochastic premature translation termination. In this review, we introduce several examples of bacterial nascent chain-based mechanisms of translation regulation by which bacteria regulate cellular functions.

Download full-text PDF

Source
http://dx.doi.org/10.1093/jb/mvad007DOI Listing

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