AI Article Synopsis
- Bariatric surgery effectively aids weight loss by potentially altering the molecular processes in subcutaneous adipose tissue (SAT), which requires more extensive research into its biological impacts.
- The study analyzed five datasets with 237 SAT samples, using advanced statistical methods to compare gene expression before and after the surgery.
- Results showed significant differences in gene expression post-operation, highlighting a decrease in immune-related functions and certain metabolic pathways related to amino/proteo-glycans.
Article Abstract
Background: Bariatric surgery is the most effective intervention for weight loss possibly through modulating subcutaneous adipose tissue (SAT) molecular programs. The post-operative molecular and biological impacts, including gene expression, deserve in-depth investigation especially given the small sample sizes in the literature.
Methods: Five existing datasets (n=237 SATs) were re-processed and corrected for batch-to-batch variation. Unsupervised approaches and robust linear mixed effect model were used to compare gene expression post- (n=126) to pre-operation (n=111).
Results: Post-operative SATs showed distinct global gene expression. Forty-four and 395 genes were over- and under-expressed post-operation (all Bonferroni <0.05). The under-expressed genes significantly enriched for 21 biological processes/pathways (all Bonferroni <0.05), 17 (76.2%) and two (9.5%) directly involved in immunity and amino/proteo-glycan metabolism, respectively.
Conclusion: Post-operative SATs might adopt distinct transcriptomic landscapes and undergo a reduction in immune-related processes and amino/proteo-glycan metabolism.
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|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC10088552 | PMC |
| http://dx.doi.org/10.7570/jomes22065 | DOI Listing |
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