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Dissecting the Global Leadership Initiative on Malnutrition Criteria in Advanced Cancer: Reduced Intake vs. Inflammation.
Clin Nutr ESPEN
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St Columba's Hospice Care, Boswall Road, Edinburgh, UK; Edinburgh Cancer Research Centre, University of Edinburgh, Edinburgh, UK.
Background & Aims: The Global Leadership Initiative on Malnutrition (GLIM) criteria have been recommended for the diagnosis of malnutrition. It requires that the patient meets at least one phenotypic criterion and at least one aetiological criterion. For the latter, the patient must either demonstrate reduced food intake or have evidence of systemic inflammation.
View Article and Find Full Text PDFExploring physiological differences in injury response by skin tone: A scoping review.
J Tissue Viability
February 2025
Skin Wounds and Trauma Research Centre, The Royal College of Surgeons in Ireland (RCSI), University of Medicine and Health Sciences, Dublin, Ireland.
Aim: To explore existing literature examining physiological differences in pressure ulcer response among individuals with differing skin tones.
Methods: This was a scoping review. Articles meeting the inclusion criteria were retrieved from electronic databases including PubMed, CINAHL, Scopus, Cochrane, and EMBASE, using the keywords "pressure ulcer," "skin pigmentation," "melanin," and "risk factor.
Hand function impairment in Systemic sclerosis: Outcomes, Mechanisms and Experience (HANDSOME) - a longitudinal observational multicentre study protocol.
BMJ Open
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Department of Rheumatology and Clinical Immunology, UMC Utrecht, Utrecht, The Netherlands.
Introduction: The majority of all patients with systemic sclerosis (SSc) experience hand function impairment. The exact cause for this impairment is yet unknown. As impaired hand function hugely impacts daily functioning and quality of life, there is a high unmet need for effective treatments.
View Article and Find Full Text PDFRole of Intestinal Barrier Disruption to Acute-on-Chronic Liver Failure.
Semin Liver Dis
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Department of Hepatology and Gastroenterology, Campus Virchow-Klinikum and Campus Charité Mitte, Charité-Universitätsmedizin Berlin, Berlin, Germany.
Acute-on-chronic liver failure (ACLF) is a severe condition in patients with decompensated liver cirrhosis, marked by high short-term mortality. Recent experimental and clinical evidence has linked intestinal dysfunction to both the initiation of ACLF as well as disease outcome. This review discusses the significant role of the gut-liver axis in ACLF pathogenesis, highlighting recent advances.
View Article and Find Full Text PDFThe role of the intestinal microbiome in cognitive decline in patients with kidney disease.
Nephrol Dial Transplant
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INSERM Unit 1018, Team 5, CESP, Hôpital Paul Brousse, Paris-Saclay University and Versailles Saint-Quentin-en-Yvelines University (UVSQ), Villejuif, France.
Cognitive decline is frequently seen in patients with chronic kidney disease (CKD). The causes of cognitive decline in these patients are likely to be multifactorial, including vascular disease, uraemic toxins, blood-brain barrier leakage, and metabolic and endocrine changes. Gut dysbiosis is common in patients with CKD and contributes to the increase in uraemic toxins.
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