Growth hormone-secreting pituitary adenoma is a common intracranial benign tumor, characterized by excessive production of growth hormone, which leads to acromegaly or giant disease. An abnormal increase in growth hormone can induce glucose metabolism disorder, which is often diagnosed and treated as type 2 diabetes, because of uncontrollable hyperglycemia, delaying the treatment of the primary disease. This paper reports the diagnosis and treatment data of a patient with growth hormone-secreting pituitary adenoma who was first diagnosed as having diabetes, and reviews the related literature to facilitate a better understanding of the disease.
: In pituitary adenomas, examinations of surgical specimens have shown that dural invasion occurs in 42-85% of cases. No studies about dura mater invasion have been conducted specifically in acromegaly patients. The aim of the present study was to evaluate the relationship between histologically dural invasion and the main features of GH-secreting adenomas.
Hypothyroidism, a condition characterized by decreased synthesis and secretion of thyroid hormones, significantly impacts intellectual development and physical growth. Current treatments, including hormone replacement therapy and thyroid transplantation, have limitations due to issues like hormone dosage control and immune rejection. Tissue engineering presents a potential solution by combining cells and biomaterials to construct engineered thyroid tissue.
The study explores brain-bone crosstalk, which is the communication between the brain and bones, and how disruptions can lead to conditions like osteoporosis.
Researchers found that Staphylococcus aureus lipoteichoic acid activates specific receptors in the brain, which affects the production of prostaglandin E2 (PGE2) and influences bone health.
PGE2 enhances the secretion of growth hormone, which helps counteract age-related bone loss, highlighting the importance of understanding these interactions for bone disease management.
Managing a patient with both pituitary hypersecretory and hyposecretory manifestations may be perplexing. We report a 14-year-old female who presented with weight gain, polyuria and polydipsia. Biochemical results were consistent with Cushing disease with central diabetes insipidus.
Purpose: Acromegaly is characterized by an insidious clinical presentation and delayed diagnosis. Longer delays are associated with more comorbidities which can persist after treatment of the growth hormone-secreting pituitary adenoma (GH-PA). Surgery is the primary therapy of GH-secreting PA, which can lead to durable remission.
