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[NMDA receptors expression activity in anaplastic astrocytomas]. | LitMetric
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[NMDA receptors expression activity in anaplastic astrocytomas].

P V Nikitin A Y Belyaev G L Kobyakov Y V Strunina S V Shugay G R Musina D Y Usachev P S Timashev

Zh Nevrol Psikhiatr Im S S Korsakova

Sechenov First Moscow State Medical University (Sechenov University), Moscow, Russia.

Published: February 2023

AI Article Synopsis

  • The study investigates the connection between NMDA receptor expression and the growth patterns and genetic features of anaplastic astrocytomas, as well as patient survival rates.
  • Researchers utilized immunofluorescent studies and polymerase chain reaction to compare NMDA receptor activity with histological results, tumor proliferation, and patient outcomes.
  • Findings reveal that NMDA receptor expression is higher in grade 3 astrocytomas without certain genetic mutations, correlating directly with tumor growth and significantly affecting prognosis for patients.

Article Abstract

Objective: To study the relationship of NMDA receptors expression activity with proliferative activity and genetic properties of anaplastic astrocytomas, as well as the survival of patients with this disease.

Material And Methods: To solve this problem, we compared the expression activity of the least studied NMDA receptors in the context under consideration, detected using immunofluorescent studies and polymerase chain reaction, with the results of histological and molecular studies, the proliferative activity of neoplasms, and the survival of patients.

Results: The expression activity of NMDA receptors is higher in astrocytomas, grade 3, which do not carry mutations in and genes. In addition, the activity of NMDA receptors expression directly correlates with proliferative activity in the tumors. The activity of NMDA receptor expression has a significant impact on the prognosis of disease-free survival.

Conclusion: We have shown for the first time the significant role of NMDA receptors in the progression of diffuse astrocytomas, which can become the basis for creating new therapeutic and diagnostic tools.

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 Source
http://dx.doi.org/10.17116/jnevro202312301197DOI Listing

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