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<PubmedArticle><MedlineCitation Status="MEDLINE" Owner="NLM" IndexingMethod="Automated"><PMID Version="1">36717916</PMID><DateCompleted><Year>2023</Year><Month>02</Month><Day>01</Day></DateCompleted><DateRevised><Year>2023</Year><Month>02</Month><Day>02</Day></DateRevised><Article PubModel="Electronic"><Journal><ISSN IssnType="Electronic">1745-6215</ISSN><JournalIssue CitedMedium="Internet"><Volume>24</Volume><Issue>1</Issue><PubDate><Year>2023</Year><Month>Jan</Month><Day>30</Day></PubDate></JournalIssue><Title>Trials</Title><ISOAbbreviation>Trials</ISOAbbreviation></Journal><ArticleTitle>Pulmonary rehabilitation integrated coached exercise training for patients with COPD: a study protocol for a randomized controlled trial.</ArticleTitle><Pagination><StartPage>69</StartPage><MedlinePgn>69</MedlinePgn></Pagination><ELocationID EIdType="pii" ValidYN="Y">69</ELocationID><ELocationID EIdType="doi" ValidYN="Y">10.1186/s13063-022-07058-2</ELocationID><Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease creating an immense burden on social health care systems. Pulmonary rehabilitation (PR) has proven to be effective in patients with COPD. However, exercise training as the basis of PR becomes extremely tedious, occasionally causing a loss of perseverance in patients. Therefore, we considered an approach that makes this technique interesting and easier to persist. The aim of this project was to explore an exercise training approach based on PR-integrated coached exercise training to promote the new exercise training approach as a form of group rehabilitation activity in the future.</AbstractText><AbstractText Label="METHODS" NlmCategory="METHODS">Participants will be&#xa0;randomly divided into the trial and control groups. The trial group will be&#xa0;treated with PR-integrated coached exercise training (plus usual care). All exercise programs will be&#xa0;guided by sports coaches with a physical education background. Meanwhile, the control group will&#xa0;receive traditional PR and home exercises, including walking and swimming. The study will&#xa0;last for 12&#xa0;weeks. The primary outcome measure is&#xa0;exercise tolerance using the 6-min walking test and secondary outcomes are&#xa0;the peak oxygen uptake of cardiopulmonary exercise tests, the COPD Assessment Test, and the St. Georges Respiratory Questionnaire. Other evaluated outcomes include changes in postbronchodilator forced expiratory volume at 1<sup>st</sup> second, forced vital capacity, body fat and muscle composition, and mental status measured using the Hamilton Anxiety and Depression Scales.</AbstractText><AbstractText Label="DISCUSSION" NlmCategory="CONCLUSIONS">This study provides a simple, feasible, repeatable, and fun exercise training approach. To the best of our knowledge, there are no randomized controlled trials in the existing literature on PR-integrated coached exercise. The protocol shared in our study can be used as a reference for exercise training in patients with COPD.</AbstractText><AbstractText Label="TRIAL REGISTRATION" NlmCategory="BACKGROUND">Ethical approval (BF2020-236-02) was obtained from the Guangdong Provincial Hospital of Chinese Medicine Human Research Ethics Committee. All participants signed an informed consent form. ChiCTR-2100043543. The registration date is 2021/02/21 and it is the third version.</AbstractText><CopyrightInformation>&#xa9; 2023. The Author(s).</CopyrightInformation></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Jing</LastName><ForeName>Yuting</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Ma</LastName><ForeName>Yuying</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510403, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y" EqualContrib="Y"><LastName>Zhang</LastName><ForeName>Hongxing</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>College of Health, Guangdong Pharmaceutical University, Guangzhou, 510006, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Wu</LastName><ForeName>Zhenhu</ForeName><Initials>Z</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Yongwen</ForeName><Initials>Y</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Li</LastName><ForeName>Haoxuan</ForeName><Initials>H</Initials><AffiliationInfo><Affiliation>The Second Clinical Medical College, Guangzhou University of Traditional Chinese Medicine, Guangzhou, 510403, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Huang</LastName><ForeName>Minling</ForeName><Initials>M</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Lin</LastName><ForeName>Lin</ForeName><Initials>L</Initials><AffiliationInfo><Affiliation>Department of Pulmonary Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China.</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Xu</LastName><ForeName>Yinji</ForeName><Initials>Y</Initials><Identifier Source="ORCID">0000-0002-9286-8207</Identifier><AffiliationInfo><Affiliation>Department of Pulmonary Critical Care Medicine, Guangdong Provincial Hospital of Chinese Medicine, Guangzhou, 510120, Guangdong Province, China. xuyinji@163.com.</Affiliation></AffiliationInfo></Author></AuthorList><Language>eng</Language><GrantList CompleteYN="Y"><Grant><GrantID>202002020042</GrantID><Agency>the Technology Planning Project of Guangzhou</Agency><Country/></Grant><Grant><GrantID>2021XK27</GrantID><Agency>the double first-class and high-level university discipline collaborative innovation team project of Guangzhou University of Chinese Medicine</Agency><Country/></Grant></GrantList><PublicationTypeList><PublicationType UI="D000078325">Clinical Trial Protocol</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType></PublicationTypeList><ArticleDate DateType="Electronic"><Year>2023</Year><Month>01</Month><Day>30</Day></ArticleDate></Article><MedlineJournalInfo><Country>England</Country><MedlineTA>Trials</MedlineTA><NlmUniqueID>101263253</NlmUniqueID><ISSNLinking>1745-6215</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011788" MajorTopicYN="Y">Quality of Life</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D029424" MajorTopicYN="Y">Pulmonary Disease, Chronic Obstructive</DescriptorName><QualifierName UI="Q000175" MajorTopicYN="N">diagnosis</QualifierName><QualifierName UI="Q000628" MajorTopicYN="N">therapy</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D015444" MajorTopicYN="N">Exercise</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005081" MajorTopicYN="N">Exercise Therapy</DescriptorName><QualifierName UI="Q000379" MajorTopicYN="N">methods</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D014797" MajorTopicYN="N">Vital Capacity</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D017079" MajorTopicYN="N">Exercise Tolerance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016032" MajorTopicYN="N">Randomized Controlled Trials as Topic</DescriptorName></MeshHeading></MeshHeadingList><KeywordList Owner="NOTNLM"><Keyword MajorTopicYN="N">Chronic obstructive pulmonary disease</Keyword><Keyword MajorTopicYN="N">Exercise training</Keyword><Keyword MajorTopicYN="N">Integration</Keyword><Keyword MajorTopicYN="N">Pulmonary rehabilitation</Keyword><Keyword MajorTopicYN="N">Randomized controlled trial</Keyword><Keyword MajorTopicYN="N">Sports</Keyword></KeywordList><CoiStatement>The funding bodies are nonprofit organizations and offer financial support for the study. The funding bodies played no part in the design of the study or collection, analysis, and interpretation of data and in writing the manuscript. The sponsor is the primary investigator. She conceived the study, led the proposal and protocol development, and holds indemnity insurance and legal liability.</CoiStatement></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="received"><Year>2022</Year><Month>4</Month><Day>18</Day></PubMedPubDate><PubMedPubDate PubStatus="accepted"><Year>2022</Year><Month>12</Month><Day>29</Day></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2023</Year><Month>1</Month><Day>31</Day><Hour>0</Hour><Minute>6</Minute></PubMedPubDate><PubMedPubDate PubStatus="pubmed"><Year>2023</Year><Month>2</Month><Day>1</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2023</Year><Month>2</Month><Day>2</Day><Hour>6</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="pmc-release"><Year>2023</Year><Month>1</Month><Day>30</Day></PubMedPubDate></History><PublicationStatus>epublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">36717916</ArticleId><ArticleId IdType="pmc">PMC9887849</ArticleId><ArticleId IdType="doi">10.1186/s13063-022-07058-2</ArticleId><ArticleId IdType="pii">10.1186/s13063-022-07058-2</ArticleId></ArticleIdList><ReferenceList><Reference><Citation>Global Initiative for Chronic Obstructive Lung Disease (GOLD). 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               <h2><a href="https://www.litmetric.com/detail/36717916/Pulmonary-rehabilitation-integrated-coached-exercise-training-for-patients-with-COPD-a-study-protoco" >Pulmonary rehabilitation integrated coached exercise training for patients with COPD: a study protocol for a randomized controlled trial.</a></h2>
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                <div class="publication-auther"><a href="https://www.litmetric.com/author/Yuting+Jing" class="tag" style="margin-bottom: 5px;">Yuting Jing</a> <a href="https://www.litmetric.com/author/Yuying+Ma" class="tag" style="margin-bottom: 5px;">Yuying Ma</a> <a href="https://www.litmetric.com/author/Hongxing+Zhang" class="tag" style="margin-bottom: 5px;">Hongxing Zhang</a> <a href="https://www.litmetric.com/author/Zhenhu+Wu" class="tag" style="margin-bottom: 5px;">Zhenhu Wu</a> <a href="https://www.litmetric.com/author/Yongwen+Li" class="tag" style="margin-bottom: 5px;">Yongwen Li</a> <a href="https://www.litmetric.com/author/Haoxuan+Li" class="tag" style="margin-bottom: 5px;">Haoxuan Li</a> <a href="https://www.litmetric.com/author/Minling+Huang" class="tag" style="margin-bottom: 5px;">Minling Huang</a> <a href="https://www.litmetric.com/author/Lin+Lin" class="tag" style="margin-bottom: 5px;">Lin Lin</a> <a href="https://www.litmetric.com/author/Yinji+Xu" class="tag" style="margin-bottom: 5px;">Yinji Xu</a></div>                   
                    <p class="mb-0 dark-color fz15 fw500 list-inline-item ml15 mb5-sm ml0-xs"><i class="flaticon-contract vam fz20 me-2"></i> Trials</p>
              
                   <p class="mb-0 dark-color fz15 fw500 list-inline-item mr15  mb5-sm ml0-xs"><i class="flaticon-place text-thm2 vam fz20 me-2"></i> Department of Pulmonary Critical Care Medicine, <a href='https://www.litmetric.com/search/Guangdong+Provincial+Hospital+of+Chinese+Medicine%5BAffiliation%5D' style='text-decoration: underline'>Guangdong Provincial Hospital of Chinese Medicine</a>, Guangzhou, 510120, Guangdong Province, China. </p>
                    
                     
                   <p class="mb-0 dark-color fz15 fw500 list-inline-item ml15 mb5-sm ml0-xs"><i class="flaticon-calendar vam fz20 me-2"></i> Published: January 2023</p>
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                   <p class="text mb30"><p class="text mt10"><em>Background</em>: Chronic obstructive pulmonary disease (COPD) is the most common chronic lung disease creating an immense burden on social health care systems. Pulmonary rehabilitation (PR) has proven to be effective in patients with COPD. However, exercise training as the basis of PR becomes extremely tedious, occasionally causing a loss of perseverance in patients. Therefore, we considered an approach that makes this technique interesting and easier to persist. The aim of this project was to explore an exercise training approach based on PR-integrated coached exercise training to promote the new exercise training approach as a form of group rehabilitation activity in the future.<BR><BR><em>Methods</em>: Participants will be randomly divided into the trial and control groups. The trial group will be treated with PR-integrated coached exercise training (plus usual care). All exercise programs will be guided by sports coaches with a physical education background. Meanwhile, the control group will receive traditional PR and home exercises, including walking and swimming. The study will last for 12 weeks. The primary outcome measure is exercise tolerance using the 6-min walking test and secondary outcomes are the peak oxygen uptake of cardiopulmonary exercise tests, the COPD Assessment Test, and the St. Georges Respiratory Questionnaire. Other evaluated outcomes include changes in postbronchodilator forced expiratory volume at 1 second, forced vital capacity, body fat and muscle composition, and mental status measured using the Hamilton Anxiety and Depression Scales.<BR><BR><em>Discussion</em>: This study provides a simple, feasible, repeatable, and fun exercise training approach. To the best of our knowledge, there are no randomized controlled trials in the existing literature on PR-integrated coached exercise. The protocol shared in our study can be used as a reference for exercise training in patients with COPD.<BR><BR><em>Trial Registration</em>: Ethical approval (BF2020-236-02) was obtained from the Guangdong Provincial Hospital of Chinese Medicine Human Research Ethics Committee. All participants signed an informed consent form. ChiCTR-2100043543. The registration date is 2021/02/21 and it is the third version.</p><table class="table table-bordered table-striped downloadTable" >
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										   <div class="value text-end">8</div>
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