Beyond housekeeping: autophagy regulates PKA signaling at synapses.

Trends Neurosci

Department of Neuroscience, Perelman School of Medicine at the University of Pennsylvania, Philadelphia, PA, 19104, USA. Electronic address:

Published: March 2023

Autophagy modulates synaptic function and plasticity, but the molecular basis for this process is largely unknown. A recent tour de force study by Overhoff and colleagues identifies a novel role for autophagy in regulating PKA signaling at synapses to modulate the organization of the postsynaptic proteome and neuronal excitability.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9990591PMC
http://dx.doi.org/10.1016/j.tins.2023.01.002DOI Listing

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