InP/ZnS quantum dots (QDs) are widely used in biomedical imaging and light-emitting component manufacturing industries, but there are few studies on their biological toxicity. In this study, we conducted experiments with rare minnow larvae and found that InP/ZnS QDs can cause liver damage. InP/ZnS QDs appeared only in the intestine of larvae and were not enriched in other parts of the larvae. The activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) and alkaline phosphatase (AKP) increased, while the decrease in bile acid. InP/ZnS QDs caused hepatic cell nuclear lysis, abnormal cytoplasmic staining, and mitochondrial cristae reduction, swelling, and fragmentation. RNA-sequencing results revealed that InP/ZnS QDs exposure treatment affected the expression of genes involved in lipid metabolism, sterol synthesis, bile acid synthesis and other pathways. The excessive production of reactive oxygen species (ROS) induced by InP/ZnS QDs may be the main source of toxicity.
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