Tunneled central venous catheters and ports provide a long-term method of delivering nutrition, hydration, or medications in children. When these devices are no longer needed, it is best practice to remove them entirely. Complications associated with having long-term venous access devices or the process of device removal include site infections, venous thrombosis or occlusion, device fracture, and possible migration of fractured fragments. We present a case of catheter fragmentation that occurred in a pediatric patient during removal of a 3-year-old left chest port that had been placed into a left superior vena cava (SVC).
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http://dx.doi.org/10.1007/s00247-023-05599-5 | DOI Listing |
Alzheimers Dement
December 2024
Seoul National University Bundang Hospital, Seongnam, Korea, Republic of (South).
Background: To investigate the neuroanatomical characteristics at the whole-brain level associated with progression from amyloid-positive preclinical to prodromal Alzheimer's disease (AD) in relation to amyloid deposition and regional atrophy.
Method: We included 45 participants with amyloid-positive preclinical AD and 135 participants with prodromal AD matched 1:3 by age, sex, and education, from participants in the Korean Longitudinal Study on Cognitive Aging and Dementia and visitors to the dementia clinic of Seoul National University Bundang Hospital. All participants underwent F-florbetaben positron emission tomography and 3D structural T1-weighted magnetic resonance imaging.
Alzheimers Dement
December 2024
Department of Neurology, University of Pennsylvania, Philadelphia, PA, USA.
Background: Amnestic mild cognitive impairment and Alzheimer's disease (aAD) exhibit degeneration of white matter (WM) tracts preceding overt cognitive decline. However, WM changes in non-amnestic AD (naAD) are understudied. We hypothesized patterns of WM degeneration would differ between aAD and naAD.
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December 2024
Universidad de La Laguna, Santa Cruz de Tenerife, Spain.
Background: The brain undergoes structural changes during aging, such as gray matter loss, enlarged ventricles, and sulcal widening. However, previous studies have primarily investigated these changes in isolation, without describing the complex spatial relationships between overall brain shape and regions. Here, we tested how gradients of expansion and compression of the global shape of the brain as well as between homologous brain regions across hemispheres are affected by age, and whether these changes further contribute to clinical impairment and cognitive deficits in older adults.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Brain Imaging and Analysis Center, Duke University Medical Center, Durham, NC, USA.
Background: Alzheimer's disease (AD) causes a steady degradation of connections inside the brain. The apolipoprotein E is a protein where one of its subtypes, APOE4, is a major genetic risk factor for developing late onset AD. Using a combination of tensor network PCA (TN-PCA) and bundle analysis, we sought to determine which specific connections differentiate APOE4 individuals relative to non-APOE4 carriers, and whether these changes increase with age.
View Article and Find Full Text PDFAlzheimers Dement
December 2024
Department of Psychiatry, University of Illinois at Chicago, Chicago, IL, USA.
Background: The APOE4 genotype appears to confer differential risk of Alzheimer's disease for women compared to men. As APOE4 effects in midlife women can be subtle (e.g.
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