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Stratifying Risk for Cognitive Decline in Older Adult Populations using the Geriatric Depression Scale.
J Psychiatry Cogn Behav
March 2024
Department of Epidemiology & Population Health, Albert Einstein College of Medicine, Bronx, NY, USA.
Objectives: Late-life psychological symptoms in older adults such as depression and apathy have been increasingly associated with increased risk of cognitive and functional decline. The goal of this study was to conduct a confirmatory factor analysis of the Geriatric Depression Scale (GDS), pooling 3 unique cohorts of older adults to 1) develop a novel measurement model that distinguishes apathy from other domains of depression including dysphoria and cognitive concern and 2) evaluate if the measurement model distinguishes older adult populations with varied risk for cognitive decline.
Methods: We pooled the baseline waves of three older adult cohorts (N=1421).
Motivators and Barriers Affecting Exercise in Patients With Parkinson's Disease.
J Clin Neurol
January 2025
Department of Neurology, Gyeongsang National University Hospital, Jinju, Korea.
Background And Purpose: Parkinson's disease (PD) significantly impacts the quality of life via both motor and nonmotor symptoms. Exercise is a valuable nonpharmacological intervention that can alleviate PD symptoms and slow disease progression. Understanding the factors that motivate and restrict exercise in PD patients is essential for promoting engagement.
View Article and Find Full Text PDFThe Impact of Brain Tumors on Emotional and Behavioral Functioning.
Cureus
December 2024
Department of General Surgery, General Medicine Practice Program and Surgery, Batterjee Medical College, Jeddah, SAU.
While the physical manifestations of brain tumors are well-documented, their impact on the emotional and psychological landscape of patients is of equal importance. Patients frequently experience a range of challenges from depression, apathy, and increased aggression to personality changes. The complexity of these changes and their effects on emotional functioning are shaped by tumor characteristics, including location, growth rate, and the corresponding hormonal imbalances.
View Article and Find Full Text PDFIrisin: A Multifaceted Hormone Bridging Exercise and Disease Pathophysiology.
Int J Mol Sci
December 2024
IRCSS Santa Lucia Foundation, European Center for Brain Research, 00143 Rome, Italy.
The fibronectin domain-containing protein 5 (FNDC5), or irisin, is an adipo-myokine hormone produced during exercise, which shows therapeutic potential for conditions like metabolic disorders, osteoporosis, sarcopenia, obesity, type 2 diabetes, and neurodegenerative diseases, including Alzheimer's disease (AD). This review explores its potential across various pathophysiological processes that are often considered independent. Elevated in healthy states but reduced in diseases, irisin improves muscle-adipose communication, insulin sensitivity, and metabolic balance by enhancing mitochondrial function and reducing oxidative stress.
View Article and Find Full Text PDFBrain network correlates of affective symptoms in aMCI.
Aging Brain
October 2024
Department of Psychiatry and Behavioral Sciences, Stanford University, USA.
Affective symptoms (i.e., depression, anxiety, and apathy) are the most prevalent subsyndrome of neuropsychiatric symptoms (NPS) in preclinical dementia, such as amnestic mild cognitive impairment (aMCI), and remain a challenge to understand and treat.
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