Nanoparticle-assisted laser-induced photothermal therapy (PTT) is a promising method for cancer treatment; yet, visualization of nanoparticle uptake and photothermal response remain a critical challenge. Here, we report a magnetic resonance imaging-active nanomatryoshka (GdO-NM), a multilayered (Au core/GdO shell/Au shell) sub-100 nm nanoparticle capable of combining T MRI contrast with PTT. This bifunctional nanoparticle demonstrates an r of 1.28 × 10 mM s, an MRI contrast enhancement per nanoparticle sufficient for T imaging in addition to tumor ablation. GdO-NM also shows excellent stability in an acidic environment, retaining 99% of the internal Gd(3). This report details the synthesis and characterization of a promising system for combined theranostic nanoparticle tracking and PTT.
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| http://dx.doi.org/10.1093/pnasnexus/pgac140 | DOI Listing |
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