AI Article Synopsis

  • A 66-year-old man with a complicated eye history developed a rare case of fungal keratitis caused by a specific filamentous fungus, despite having no prior eye trauma.
  • His treatment involved multiple interventions, including antifungal medications, corneal surgeries, and even hospitalizations for complications, but the infections recurred and led to severe complications, including corneal perforation.
  • The case highlights the challenges and potential for recurrence in treating this type of fungal keratitis, ultimately leading to the patient's decline in health due to other underlying issues.

Article Abstract

Purpose: To report the initial case of microbial keratitis caused by , a rare cause of fungal keratitis.

Observations: A 66-year-old gentleman with a complex right eye (OD) ocular history including herpes simplex virus infectious epithelial keratitis with subsequent neurotrophic keratopathy, and prior combined and fungal keratitis presented with pain OD in the absence of an antecedent trauma. The patient was found to have a filamentous fungal keratitis, which was subsequently cultured and identified as by the laboratory. Despite topical and oral antifungal treatment based on sensitivities determined by the lab, the patient ultimately required intrastromal and subconjunctival antifungal injections, corneal crosslinking, and superficial keratectomy with amniotic membrane to clinically improve. The fungal keratitis recurred twice, with each occurrence rapidly progressing to corneal perforation. Months after the second penetrating keratoplasty, the patient's mental status declined due to multiorgan failure. An occult pulmonary malignancy was discovered during this hospital stay, and the patient was lost to follow-up after entering hospice.

Conclusions And Importance: We report a unique case of fungal keratitis caused by and the subsequent management, including both medical and surgical interventions Despite a multimodal treatment regimen, this case demonstrates the recalcitrant and potentially recurrent nature of fungal keratitis caused by .

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC9876777PMC
http://dx.doi.org/10.1016/j.ajoc.2023.101800DOI Listing

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